Results 81 to 90 of about 10,698,248 (292)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

University High Highlights 5/28/1965 [PDF]

open access: yes, 1965
This is the student newspaper from University High School, the high school that was on the campus of Western Michigan University, then called University High Highlights, in ...
, University High School
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

University High Highlights 3/29/1961 [PDF]

open access: yes, 1961
This is the student newspaper from University High School, the high school that was on the campus of Western Michigan University, then called University High Highlights, in ...
, University High School
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

LİSE ÖĞRENCİLERİNİN BEDEN EĞİTİMİ DERSİNE YÖNELİK TUTUMLARI: ANKARA’DA BALÂ İLÇESİ ÖRNEĞİ

open access: yesSpormetre Beden Eğitimi ve Spor Bilimleri Dergisi, 2018
Ortaöğretimöğrencilerinin beden eğitimi ve spor (BES) dersine ilişkin tutumlarınıinceleyen çalışmaların sonuçları değişkendir; araştırmalar sıklıkla belirlideğişkenlere ilişkin benzer biçimde anlamlı fark bulurken farklı sonuçlar verenaraştırmalar da ...
Pınar Yaprak, Esra Yıldız
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Initiatives of Female Empowerment in Computing Implemented at the High School Level: A Systematic Mapping

open access: yesSocieties
Gender disparities in technology are evident, and affirmative actions are necessary to increase female representation. This article is part of an umbrella project that systematically maps related studies and aims to understand the current literature on ...
Ramayane Bonacin Braga   +4 more
doaj   +1 more source

Contribuições da psicologia para a formação do técnico em enfermagem: concepções dos alunos Contribuciones a la psicología de la formación técnica en enfermería: concepciones de los estudiantes Contributions of the psychology to the technical training in nursing: conceptions of students

open access: yesPsicologia em Estudo, 2010
O presente trabalho é uma pesquisa de campo qualitativa e descritiva com o objetivo de investigar as concepções de estudantes de um curso técnico em enfermagem no Estado do Rio de Janeiro sobre suas expectativas em relação à disciplina "Psicologia ...
Fernanda Azevedo Esquerdo   +1 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

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