Results 81 to 90 of about 10,661,271 (293)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Initiatives of Female Empowerment in Computing Implemented at the High School Level: A Systematic Mapping

Societies
Gender disparities in technology are evident, and affirmative actions are necessary to increase female representation. This article is part of an umbrella project that systematically maps related studies and aims to understand the current literature on ...
Ramayane Bonacin Braga, Mirelle Amaral de São Bernardo, Sara Luiz de Farias, Thalia Santos de Santana, Marcos de Moraes Sousa   +4 more
doaj   +1 more source

LİSE ÖĞRENCİLERİNİN BEDEN EĞİTİMİ DERSİNE YÖNELİK TUTUMLARI: ANKARA’DA BALÂ İLÇESİ ÖRNEĞİ

Spormetre Beden Eğitimi ve Spor Bilimleri Dergisi, 2018
Ortaöğretimöğrencilerinin beden eğitimi ve spor (BES) dersine ilişkin tutumlarınıinceleyen çalışmaların sonuçları değişkendir; araştırmalar sıklıkla belirlideğişkenlere ilişkin benzer biçimde anlamlı fark bulurken farklı sonuçlar verenaraştırmalar da ...
Pınar Yaprak, Esra Yıldız
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Contribuições da psicologia para a formação do técnico em enfermagem: concepções dos alunos Contribuciones a la psicología de la formación técnica en enfermería: concepciones de los estudiantes Contributions of the psychology to the technical training in nursing: conceptions of students

Psicologia em Estudo, 2010
O presente trabalho é uma pesquisa de campo qualitativa e descritiva com o objetivo de investigar as concepções de estudantes de um curso técnico em enfermagem no Estado do Rio de Janeiro sobre suas expectativas em relação à disciplina "Psicologia ...
Fernanda Azevedo Esquerdo, Renata Fabiana Pegoraro   +1 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Some features of the competitive relations in high school

Известия высших учебных заведений: Геология и разведка, 2017
An analysis of the competitiveness of the high school is considered as a patch of the subsystems, which level of development determines its competitive advantages. The subsystems have been distinguished: basic high school activity, additional high school
E. S. Kushel’
doaj   +1 more source

University High Highlights 5/25/1960 [PDF]

, 1960
This is the student newspaper from University High School, the high school that was on the campus of Western Michigan University, then called University High Highlights, in ...
, University High School
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source