Results 91 to 100 of about 3,626,576 (308)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Why Are Students Dropping Out of School? The Factors that Contribute to the United States High School Dropout Rate [PDF]
, 2010 With a very fluctuating economy and an unstable job market, a high school diploma as well as a continued education is becoming extremely important. An increasing amount of businesses will not even consider a job application unless a person has a high ...
Lund, Christopher
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Pathways to College Preparatory Advanced Academic Offerings in the Anchorage School District [PDF]
, 2016 Prepared for: CITC’s Anchorage Realizing Indigenous Student ExcellenceThere are many ways a child in the Anchorage School District (ASD) can access advanced course offerings. To a parent these pathways may seem complex.
Frazier, Rosyland, Hirshberg, Diane
core +3 more sources
The Relationships between High School Subjects in terms of School Satisfaction and Academic Performance in Mexican Adolescents [PDF]
, 2019 Adolescents’ academic performance and the way it is related to their subjective wellbeing are issues of great interest across educational systems. The purpose of this study was to ascertain how satisfaction with high school subjects can predict school ...
Baena Extremera, Antonio +2 more
core +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Learning From Each Other, Serving Together
, 2005 At Trinity Christian College we believe that incorporating service and scholarship into teaching is congruent with the transformational nature of Trinity’s mission.
Powell, Patricia L.
core
RWU SCS is Creating Pathways for All Students [PDF]
, 2017 A look at the programs offered for middle school, high school and nontraditional students at RWU\u27s School of Continuing ...
Siliezar, Juan
core +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source