Results 91 to 100 of about 16,294,395 (304)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
, 2017 Toledo Central High School was bounded by Madison, Michigan, Adams and 10th Streets. Toledo Central High School occupied this location from approximately 1898-1914. Later, this would become the site of the Toledo Lucas County Public Library. An alternate
Toledo Central High School (Toledo, Ohio)
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
School Choice and Student Performance: Are Private Schools Really Better? [PDF]
Are private schools really better than public schools, or is it simply that better students attend private schools? Although a number of recent studies find that students perform better in private schools (more specifically, Catholic schools), others do ...
D. N. Figlio, J. A. Stone
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Attracting and Retaining Teachers in High-Need Schools: Do Financial Incentives Make Financial Sense? [PDF]
This study synthesizes what we know and do not know about policies to attract and retain teachers in high-need schools and assesses the relative cost-effectiveness of two types of policies. Research consistently shows that teacher quality is likely to be
Jennifer Imazeki
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Faith Primary Schools: Better Schools or Better Pupils? [PDF]
We provide estimates for the effect of attending a Faith school on educational achievement using a census of primary school pupils in England. We argue that there are no credible instruments for Faith school attendance in this context.
Gibbons, Steve, Silva, Olmo
core
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
تحلیل آرکهتایپی قصۀ «ملک ابراهیم و دختران پاشاه مصر» [PDF]
فرهنگ و ادبیات عامهقصههای پریان بهعنوان بخش بزرگی از ادبیات روایی و شفاهی عامه، سرشار از رمز و رازهای نمادین هستند. کشف این رمز و رازها ما را به جهان بزرگ درون انسان، هدایت میکند.
معصومه یاسمی فر +2 more
doaj