Results 201 to 210 of about 21,717,715 (348)

Nicardipine is a putative EED inhibitor and has high selectivity and potency against chemoresistant prostate cancer in preclinical models. [PDF]

Br J Cancer, 2023
Li X, Chen Y, Bai L, Zhao R, Wu Y, Xie ZR, Wu JM, Bowen NJ, Danaher A, Cook N, Li D, Qui M, Du Y, Fu H, Osunkoya AO, Kucuk O, Wu D.   +16 more
europepmc   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

High selectivity framework polymer membranes chemically tuned towards fast anion conduction. [PDF]

Nat Commun
Fang J, Zhang G, Goulet MA, Zuo P, Zhou Y, Li H, Jiang J, Guiver MD, Yang Z, Xu T.   +9 more
europepmc   +1 more source

High Selectivity of 8-Hydroxyquinoline on Leishmania (Leishmania) and Leishmania (Viannia) Species Correlates with a Potent Therapeutic Activity In Vivo. [PDF]

Pharmaceuticals (Basel), 2023
Lima SKS, Jesus JA, Raminelli C, Laurenti MD, Passero LFD.   +4 more
europepmc   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

SARS-CoV-2 and omicron variant detection with a high selectivity, sensitivity, and low-cost silicon bio-nanosensor. [PDF]

Nano Sel, 2022
Leonardi AA, Sciuto EL, Lo Faro MJ, Fazio B, Rizzo MG, Calabrese G, Francioso L, Picca R, Nastasi F, Mancuso G, Spinella C, Knoll W, Irrera A, Conoci S.   +13 more
europepmc   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Further Insight in the High Selectivity of Pb²⁺ Removal over Cd²⁺ in Natural and Dealuminated Rich-Clinoptilolite. [PDF]

Int J Mol Sci
Durán-Avendaño YS, Hernández NC, Ruiz-Salvador AR, Abatal M.   +3 more
europepmc   +1 more source

High Selectivity Fuel from Efficient CO₂ Conversion by Zn-Modified rGO and Amine-Functionalized CuO as a Photocatalyst. [PDF]

Materials (Basel), 2023
Damastuti R, Susanti D, Prasannan A, Hsiao WW, Hong PD.   +4 more
europepmc   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source