Results 261 to 270 of about 21,717,715 (348)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Detection of PPB-Level H₂S Concentrations in Exhaled Breath Using Au Nanosheet Sensors with Small Variability, High Selectivity, and Long-Term Stability. [PDF]

ACS Sens
Kato T, Tanaka T, Uchida K.
europepmc   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung, E‐nae Cheong, Jungmin So, Heung‐Won Kang, Yangsean Choi, Eun‐Jae Lee, Hyunjin Kim, Young‐Min Lim   +7 more
wiley   +1 more source

Neuropsychiatric Symptoms Mimicking Dementia in a Patient Treated With Imatinib

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Tyrosine kinase inhibitors are the cornerstone of chronic myeloid leukemia treatment. Newer agents have more potency and a broader spectrum of action, but also a higher potential for neuropsychiatric side effects. We present a case of a patient on imatinib who developed progressive cognitive, mood, and behavioral alterations.
Ashley Jones, Samuele Bonomi, Keith E. Stockerl‐Goldstein, Randall J. Bateman   +3 more
wiley   +1 more source

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt, Marius Ygonia, Ali Manouchehrinia, Philippe Lefrançois, Ingrid Kockum, Adil Harroud   +5 more
wiley   +1 more source

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High-Selectivity Frequency-Selective Rasorber With Tunable Absorptivity

IEEE Transactions on Antennas and Propagation, 2023
This article presents a high-selectivity frequency-selective rasorber (FSR) with an adjustable out-band absorptivity property. This rasorber is composed of a dynamic absorptive frequency-selective surface (AFSS) on the top, with p-i-n diodes employed to ...
Dingwang Yu, Yanfei Dong, Zhuohang Zhang, Mingtuan Lin, Lujing Han   +4 more
openaire   +2 more sources

Dislocated Bilayer MOF Enables High‐Selectivity Photocatalytic Reduction of CO2 to CO

Advances in Materials, 2023
The highly selective photoreduction of CO2 into valuable small‐molecule chemical feedstocks such as CO is an effective strategy for addressing the energy crisis and environmental problems.
Jinxia Liang, Hao Yu, Junjuan Shi, Bao Li, Lixin Wu, Ming Wang   +5 more
semanticscholar   +1 more source

Achieving High Selectivity in Photocatalytic Oxidation of Toluene on Amorphous BiOCl Nanosheets Coupled with TiO2.

Journal of the American Chemical Society, 2023
The inert C(sp3)-H bond and easy overoxidation of toluene make the selective oxidation of toluene to benzaldehyde a great challenge. Herein, we present that a photocatalyst, constructed with a small amount (1 mol %) of amorphous BiOCl nanosheets ...
Hao Wang, Chen Cao, Dongfeng Li, Yongxin Ge, Ruotian Chen, Rui Song, Wensheng Gao, Xiuli Wang, Xintan Deng, Hongjun Zhang, B. Ye, Zelong Li, Can Li   +12 more
semanticscholar   +1 more source