Results 81 to 90 of about 21,717,715 (348)

Single‐Atom Cu Stabilized on Ultrathin WO2.72 Nanowire for Highly Selective and Ultrasensitive ppb‐Level Toluene Detection

Advanced Science, 2023
Various catalysts are developed to improve the performance of metal oxide semiconductor gas sensors, but achieving high selectivity and response intensity in chemiresistive gas sensors (CGSs) remains a significant challenge.
Peng Wang, Shisong Guo, Zhixiang Hu, Licheng Zhou, Tiankun Li, Shiliang Pu, Hui Mao, Hong Cai, Zhenfeng Zhu, Bingbing Chen, Hua‐Yao Li, Huan Liu   +11 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Zinc metal-organic frameworks- graphene quantum dots nanocomposite mediated highly sensitive and selective fluorescence “On-Off-On” probe for sensing of quercetin

Acta Chimica Slovenica, 2023
Presently, there is a necessity to design novel methods because of quercetin's significant biological relevance. Therefore, we developed the rose petal-derived graphene quantum dots embedded zinc metal organic frameworks (RP-GQDs@Zn-MOFs) based ...
Sopan Nangare, Premnath Sangale, Ashwini Patil, Pravin Onkar Patil   +3 more
doaj   +1 more source

Rational Design, Synthesis and Biological Evaluation of Pyrimidine-4,6-diamine derivatives as Type-II inhibitors of FLT3 Selective Against c-KIT. [PDF]

, 2018
FMS-like Tyrosine Kinase 3 (FLT3) is a clinically validated target for acute myeloid leukemia (AML). Inhibitors targeting FLT3 have been evaluated in clinical studies and have exhibited potential to treat FLT3-driven AML.
Bharate, Jaideep B, Ding, Lucky, Frett, Brendan, Lakkaniga, Naga Rajiv, Li, Hong-Yu, McConnell, Nicholas, Naresh, Gunaganti, Shah, Neil P, Zhang, Lingtian   +8 more
core   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Thermally assisted ion beam etching of polytetrafluoroethylene, a new technique for high aspect ratio etching of MEMS [PDF]

, 1996
In micromechanics, the etching of high aspect ratio structures in polymers is a prime technology. Normally, oxygen-based reactive ion etching or the LIGA technique are used to achieve this goal.
Berenschot, Erwin, Burger, Gert-Jan, Elwenspoek, Miko, Gardeniers, Han, Jansen, Henri   +4 more
core   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Promoting H2O2 production via 2-electron oxygen reduction by coordinating partially oxidized Pd with defect carbon. [PDF]

, 2020
Electrochemical synthesis of H2O2 through a selective two-electron (2e-) oxygen reduction reaction (ORR) is an attractive alternative to the industrial anthraquinone oxidation method, as it allows decentralized H2O2 production. Herein, we report that the
Chang, Qiaowan, Chen, Jingguang G, Chen, Zheng, Denny, Steven R, Gao, Hongpeng, Lee, Ji Hoon, Mostaghimi, Amir Hassan Bagherzadeh, Siahrostami, Samira, Xin, Huolin L, Zhang, Pu, Zhang, Ying, Zhao, Xueru   +11 more
core  

Scalable Production of Highly-Sensitive Nanosensors Based on Graphene Functionalized with a Designed G Protein-Coupled Receptor [PDF]

, 2014
We have developed a novel, all-electronic biosensor for opioids that consists of an engineered mu opioid receptor protein, with high binding affinity for opioids, chemically bonded to a graphene field-effect transistor to read out ligand binding.
Crook, Alexander, Han, Gang Hee, Hong, Sung Ju, Johnson, A. T. Charlie, Lerner, Mitchell B., Liu, Renyu, Matsunaga, Felipe, Park, Yung Woo, Perez-Aguilar, Jose Manuel, Saven, Jeffery G., Xi, Jin   +10 more
core   +4 more sources