Results 151 to 160 of about 18,960,429 (284)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Lincoln High School, 1991 Bumblebee, Volume 42
, 1991 Yearbook for Lincoln High School in Port Arthur, Texas, which includes photographs of and information about the school, student body, teachers, and ...
Lincoln High School
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Beauty at High Precision / High Sensitivity
, 2019 Opening lecture at Beauty 2019, 30 September–4 October 2019, Ljubljana (Slovenia). Mouse over figures and text for (hidden) links.
openaire +2 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Graduation program, Crisfield High School, 1905
, 1905 Harry Clifton Byrd's graduation program from Crisfield High School, dated 1905.
Crisfield High School
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
[Graduation Exercise of the Teachers College High School]
, 1933 Commencement program for the 1934 Teachers College High School graduating class. Printed on the cover are the words, "Graduation Exercise of the Teachers College High School. College Auditorium.
Teachers College High School
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
[Graduation Exercises of the Teachers College High School]
, 1942 Graduation Exercises for the 1942 Teachers College High School. Printed on the cover are the words, "Graduation Exercises of the Teachers College High School Main Auditorium May Twenty-Eight Nineteen Hundred Forty-Two Eight P.M." The program includes the
Teachers College High School
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