Results 31 to 40 of about 105,237 (218)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mechanical properties and energy absorption of CoCrNi functionally graded TPMS cellular structures

Journal of Materials Research and Technology
Functionally gradient triply periodic minimal surface (TPMS) structures are found widespread applications in fields such as aerospace and defense engineering, owing to flexible modulation of lightweight and energy-absorbing properties.
Zhaoyi Wang, Junxian Zhou, Yunzhuo Lu, Dongming Li, Deyu Yue, Xu Zhang, Bingzhi Chen   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Fatigue performance of bogie weld roots: Failure analysis and numerical modeling

Results in Engineering
In engineering practice, accurately identifying root failure mechanisms and quantitatively evaluating fatigue performance improvements in the absence of load spectrum conditions remains a challenge.
Shaoze Zhou, Zhen Zhang, Desong Meng, Jun Zhang   +3 more
doaj   +1 more source

Research on speed control of high-speed train based on multi-point model [PDF]

Archives of Transport, 2019
The traditional train speed control research regards the train as a particle, ignoring the length of the train and the interaction force between carriages.
Tao Hou, Yang-yang Guo, Hong-xia Niu
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Sound and mechanical impedance behaviors observed in multifunctional modular bio-inspired lattice metamaterials

Materials & Design
Noise and impact hazards are ubiquitous in engineering applications, creating an urgent demand for multifunctional materials capable of absorbing both acoustic and stress wave energy.
Shiyi Wang, Xi Wang, Ruixian Qin, Qijian Li, Bingzhi Chen   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Laser additive manufacturing of hierarchical multifunctional chiral metamaterial with distinguished damage-resistance and low-frequency broadband sound-absorption capabilities

Materials & Design
Traditional materials or advanced artificially engineered metamaterials are incapable of effectively addressing the simultaneous challenges of impact energy hazards and low-frequency noise.
Xi Wang, Ruixian Qin, Jiaming Lu, Minghao Huang, Xu Zhang, Bingzhi Chen   +5 more
doaj   +1 more source

Influence of Nose-slenderness Ratio on Air Pressure Pulse of High-speed Trains Passing Each Other

Journal of Applied Science and Engineering, 2021
The strength of side windows, the stability of train operation, and the comfort of passengers will be affected by air pressure fluctuations when the high-speed train meets.
Lin Ma, Zihao Xie, Weiyu Chen, ZhenfengWu   +3 more
doaj   +1 more source