Results 121 to 130 of about 14,831,642 (287)

Increasing durum wheat adaptation to drought by exploring genetic resources with shoot and root high throughput phenotyping

, 2019
The Mediterranean region is one of the main region affected by the impact of global climate change, with a strong drawbacks on agricultural productions and thus on food security.
PIGNONE D, LORETO F, FIORANI F, DANZI D, NAGEL KA, PETROZZA A, CELLINI F, GALINSKI A, JANNI M, SUMMERER S   +9 more
core  

FluorATOM: high-throughput imaging flow cytometry for synchronized biophysical and biomolecular phenotyping

, 2020
Multiplexed asymmetric-detection time-stretch optical microscopy (multi-ATOM) has recently been developed to enable high-throughput quantitative phase imaging flow cytometry, from which single-cell biophysical properties can be measured at large scale ...
Kwong, A, Wong, KKY, Lee, KCM, Wang, M, Shin, VY, Tsia, KKM, Cheuk, WYI, So, HKH   +7 more
core   +1 more source

In‐House Manufacturing of 3D ECM Culture Chips via Vacuum Thermoforming for Enhanced Imaging Applications

Advanced Materials Technologies, EarlyView.
Desktop vacuum thermoforming enables rapid, low‐cost fabrication of 96‐channel polystyrene culture chips with very thin imaging interfaces. The resulting platform supports cell lines, primary cells, and patient‐derived organoids, and enables high‐resolution confocal microscopy and single‐cell visualization, providing an accessible approach for advanced
Aleksandra Fomina, Adam Tam, Jennifer Lam, Nila C. Wu, Nancy T. Li, Alison P. McGuigan   +5 more
wiley   +1 more source

Exploring wheat genetic resources with shoot and root high-throughput phenotyping to improve adaptation to drought

, 2018
Water availability is a major environmental stress threatening crops production worldwide, which impedes crop performance at all growth stages. Among a wide range of traits linked to drought resistance the root system plays an essential role in ensuring ...
PIGNONE D, LORETO F, FIORANI F, DANZI D, NAGEL KA, PETROZZA A, CELLINI F, GALINSKI A, JANNI M, SUMMERER S   +9 more
core  

Turning Light Into Matter: Programmable Microstructures Via Dose Control in Two‐Photon Polymerization

Advanced Optical Materials, EarlyView.
This work augments two‐photon polymerization with point‐wise dose control, enabling structures with heterogeneous material properties such as refractive index. An open source toolbox and superior calibration methodology for the refractive index pave the way for bio‐mimicking or numerically optimized structure designs, and enhance the synergy between 3D
Michał Ziemczonok, Koen Vanmol
wiley   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

FIELD PHENOTYPING: REMOTE AND PROXIMAL HIGH-THROUGHPUT PLATFORMS IN SOUTHERN ITALY

High-throughput field phenotyping offers dramatic improvements in the determination of key crop traits, enabling the collection of objective, repeatable and non-destructive measurements through the growing ...
FRANCESCO CELLINI, ANDRÉ PIERRE MARIE FABBRI, ADRIANO CONTE, ANDRE’ DACCACHE, GIOVANNI MARINO, GIULIA ATZORI, VINCENZO MONTESANO, MAURO CENTRITTO, MATTHEW HAWORTH, DONATELLA DANZI   +9 more
core  

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

Thermography to assess grapevine status and traits opportunities and limitations in crop monitoring and phenotyping – a review

, 2021
Mestrado em Engenharia de Viticultura e Enologia (Double degree) / Instituto Superior de Agronomia. Universidade de Lisboa / Faculdade de Ciências.
La Fata, Antonio
core  

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source