Programmable Paracrine‐Mimetic Microneedle System for Temporal Regulation of Cardiac Repair
Temporal signaling is encoded into a programmable paracrine‐mimetic microneedle patch via tris(2,2'‐bipyridyl)dichlororuthenium(II) hexahydrate/sodium persulfate‐tuned hydrogel microparticles that deliver TGF‐β, IGF‐1, and VEGF over phase‐matched 7‐, 14‐, and 28‐day windows.
Yichen Dai +18 more
wiley +1 more source
High-Throughput Phenotyping for Agronomic Traits in Cassava Using Aerial Imaging. [PDF]
Nascimento JHB +5 more
europepmc +1 more source
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo +10 more
wiley +1 more source
Advancing Crop Resilience Through High-Throughput Phenotyping for Crop Improvement in the Face of Climate Change. [PDF]
Nguyen HT +12 more
europepmc +1 more source
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong +17 more
wiley +1 more source
Frost tolerance improvement in pea and white lupin by a high-throughput phenotyping platform. [PDF]
Franguelli N +4 more
europepmc +1 more source
Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery
A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li +9 more
wiley +1 more source
Integrating metabolomics and high-throughput phenotyping to elucidate metabolic and phenotypic responses to early-season drought stress in Nordic spring wheat. [PDF]
Wonneberger R +10 more
europepmc +1 more source
Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan +5 more
wiley +1 more source
High throughput phenotyping in soybean breeding using RGB image vegetation indices based on drone. [PDF]
Alves AKS +6 more
europepmc +1 more source

