Results 201 to 210 of about 1,871,500 (313)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Task-Evoked Functional Activation and Coupling With CSF Flow Detected in the Human Brain With Ultrashort Echo Time fMRI at 7 T. [PDF]

NMR Biomed
Ponticorvo S, Paasonen E, Filip P, Rothman DL, Valjakka JS, Gröhn O, Michaeli S, Mangia S.   +7 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Estimating high-resolution albedo for urban applications. [PDF]

Nat Commun
Fork D, Wesley EJ, Banerjee S, Batchu V, Chennapragada A, Crossan K, Cronkite-Ratcliff B, Delich E, Goulden T, Kansal M, Kemp J, Mackres E, Mayer Y, Milman R, Platt JC, Prabhakara S, Prasad G, Shetty S, Stanton C, Sun W, Hutyra LR.   +20 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Enhancing resolution and image quality in musculoskeletal MRI using deep learning reconstruction. [PDF]

Eur Radiol Exp
Porta M, Agresti G, Laganà MM, Orofino S, Pangaro S, Carapella N, Bonaffini PA, Bernasconi P, Genovese EA, Sironi S, Aliprandi A.   +10 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Evolving SPECT-CT technology. [PDF]

Br J Radiol
Willowson KP, Bailey DL.
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Cognitive Mechanisms of Referential Ambiguity Resolution in L2 Russian by Chinese Learners: Evidence from Eye-Tracking. [PDF]

J Eye Mov Res
Ran T, Guo L, Xu H.
europepmc   +1 more source