Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Which guidelines from North America and Europe on cardiovascular risk management with statins have high utility in family medicine? [PDF]
Can Fam PhysicianSupper I +7 more
europepmc +1 more source
Mining of high utility-probability sequential patterns from uncertain databases. [PDF]
PLoS One, 2017 Zhang B, Lin JC, Fournier-Viger P, Li T.
europepmc +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Aim high, stay private: differentially private synthetic data enables public release of behavioral health information with high utility. [PDF]
JAMIA OpenGhasemizade M +6 more
europepmc +1 more source
Phytochemical and biotechnological studies on Schisandra chinensis cultivar Sadova No. 1-a high utility medicinal plant. [PDF]
Appl Microbiol Biotechnol, 2018 Szopa A +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
High utility of DNA barcoding for species identification and cryptic diversity in Korean aphids (Hemiptera: Aphididae). [PDF]
Sci RepKang Y +5 more
europepmc +1 more source
An incremental high-utility mining algorithm with transaction insertion. [PDF]
ScientificWorldJournal, 2015 Lin JC, Gan W, Hong TP, Zhang B.
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source