Results 101 to 110 of about 306,546 (292)

Efficient Mining of Frequent High Average-Utility Occupancy Sequences

open access: yes
Frequent High Utility Occupancy Sequence Mining (FHUOSM), which integrates both frequency and utility occupancy, has recently has become a key research focus with broad real-world applicability.
Dương, Văn Hải   +4 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Mining High Utility Patterns Over Data Streams [PDF]

open access: yes, 2016
Mining useful patterns from sequential data is a challenging topic in data mining. An important task for mining sequential data is sequential pattern mining, which discovers sequences of itemsets that frequently appear in a sequence database.
Kermani, Morteza Zihayat
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Scalable high-utility pattern mining from data streams

open access: yes, 2022
Traditional high-utility mining mainly focuses on improving the efficiency of discovering high utility patterns from static databases based on a simplified assumption that the unit utility for a given item is a constant. However, not much research effort
Mai, Jiaxing
core  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

AN EFFECTIVE WAY OF MINING HIGH UTILITY ITEMSETS FROM LARGE TRANSACTIONAL DATABASES [PDF]

open access: yes, 2016
The main aim of this project is to generate the high utility (profitable) itemsets in a parallel environment, by considering the both profit and quantity of each item. The parallel mining of high utility itemsets will take very less time than mining with
Amarendra, Dr. K., Prasad, Chadaram
core  

Incremental High Fuzzy Utility Itemset Mining

open access: yes, 2022
In the field of data mining, frequent-pattern mining is used for handling binary databases. Utility mining addresses this limitation by considering item utilities and quantities when discovering high utility itemsets. In addition, the fuzzy-set theory is
Hung, Wei-Teng
core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

FHUQI-Miner: Fast high utility quantitative itemset mining

open access: yes, 2021
High utility itemset mining is a popular pattern mining task, which aims at revealing all sets of items that yield a high profit in a transaction database. Although this task is useful to understand customer behavior, an important limitation is that high
Nouioua, Mourad   +4 more
core  

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