Results 171 to 180 of about 1,816,478 (387)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Boost‐integrated LCL resonant converter with high voltage gain [PDF]

, 2019
Yisheng Yuan, Zhongyi Zhang, Xianglong Mei   +2 more
openalex   +1 more source

HIGH VOLTAGE GAIN DC-DC CONVERTER WITH SWITCHING INDUCTOR AND TWO SWITCHES

, 2023
Roja Vadlamudi, Karpagavalli, L Piansangsan, R Majeed, A Chughtai, H Vaidya, S Lindiya, S Palani, K Vijayarekha, Y Yang, D Li, D Wang, M Qin, J.-L Xie, Y Kishor, R Patel, Amutha Vijai, Mohamad Priya, Vinoth, A Ahmad, R Singh, A Beig, B Axelrod, Y Berkovich, A Ioinovici, B Axelrod, Y Berkovich, A Ioinovici, H Do, D Li, P Loh, M Zhu, F Gao, F Blaabjerg, M Zhu, X Li, X Cai, K Kim, H Cha, S Park, I. -O Lee   +40 more
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Optimized ultra high voltage gain DC–DC converter with current stress reduction for photovoltaic application

IET Power Electronics
This paper presents a non‐isolated DC‐DC converter designed to validate ultra‐high voltage gain using a modified double boost mode. The objective is to achieve exceptionally high voltage gain by integrating a modified triple boost technique (MTBT ...
Ammar Falah ALgamluoli, Xiaohua Wu, Hayder K. Jahanger   +2 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Voltage Regulated Single Switch DC-DC Converter with High Voltage gain

International Journal of Engineering Research and, 2015
null Susmi. K. M, null Meera. G, null Remya. M. S   +2 more
openaire   +1 more source

A Novel PI Converter based High Voltage Gain DC – DC Converter

, 2014
M.Su jith, S.Ne elan, S.Asok Kumar, J.A sha   +3 more
openalex   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source