Results 71 to 80 of about 135,342 (262)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Novel Interleaved Converter with Extra-High Voltage Gain to Process Low-Voltage Renewable-Energy Generation

Energies, 2016
This paper presents a novel interleaved converter (NIC) with extra-high voltage gain to process the power of low-voltage renewable-energy generators such as photovoltaic (PV) panel, wind turbine, and fuel cells. The NIC can boost a low input voltage to a
Chih-Lung Shen, Po-Chieh Chiu, Yan-Chi Lee   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A High Voltage Gain Single-Switch Converter With Soft-Switching and EMI Mitigation

International Transactions on Electrical Energy Systems
In this study, a high step-up DC–DC conversion topology incorporating soft-switching behavior is introduced. The proposed structure employs a combination of coupled-inductor boosting and switched-capacitor enhancement to achieve a substantial increase in
Ali Janghorban, Majid Delshad, Bahador Fani   +2 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

High voltage gain switched z‐source inverter with low current stress

IET Power Electronics
This paper proposes a switched Z‐source inverter with high voltage gain and low current stress on elements. Also, a new switching method corresponding to the proposed topology is introduced.
Golaleh Zarei, Ebrahim Babaei, Mohammad Bagher Bannae Sharifian, Hadi Aghaei, Elias Shokati Asl   +4 more
doaj   +1 more source

A Novel High Step-Up DC-DC Converter Based on KY Converter [PDF]

Journal of Electrical and Electronics Engineering, 2017
High voltage gain dc-dc converters are widely using in solar systems, fuel cell and automobile electronic lamp ballast. The voltage gain of the classic converters is limited considering the issues such as the high voltage stress on the switch and diode ...
AJDARFAEGHI BONAB Hossein, BANAEI Mohamad Reza   +1 more
doaj  

High step-up interleaved boost converter utilising stacked half-bridge rectifier configuration

The Journal of Engineering, 2019
This paper proposes a solution to complement the insufficient voltage gain and voltage stress distribution of classical interleaved boost converter in high step-up application.
Musbahu Muhammad, S. Lambert, M. Armstrong, V. Pickert   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source