Results 61 to 70 of about 8,004 (311)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Enhanced Speed Characteristics of High-Torque-Density BLDC Motor for Robot Applications Using Parallel Open-End Winding Configuration

Actuators
High-torque-density motors are essential in humanoid, wearable, and rehabilitation robots due to their ability to minimize gear ratios, improve back-drivability, and support compact joint design.
Junghwan Park, Handdeut Chang, Chaeeun Hong   +2 more
doaj   +1 more source

Investigation on the Resonant Oscillations in an 11 kV Distribution Transformer under Standard and Chopped Lightning Impulse Overvoltages with Different Shield Placement Configurations

Energies, 2019
This paper presents an investigation on the resonant oscillations of an 11 kV layer-type winding transformer under standard and chopped lightning impulse overvoltage conditions based on calculated parameters. The resistances, inductances and capacitances
Avinash Srikanta Murthy, Norhafiz Azis, Mohd Fairouz Mohd Yousof, Jasronita Jasni, Mohammad Lutfi Othman, Mohd Aizam Talib, Bhaba Priyo Das   +6 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Avaliação dos ensaios de descargas parciais e de rotor bloqueado como formas de detecção de defeitos de fabricação em estatores de motores de indução monofásicos [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Mecânica, Florianópolis, 2013.Como parte da garantia da qualidade na produção de estatores de motores de indução monofásicos, são
Cristancho Caviativa, Jorge Alejandro
core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

A change-detection algorithm for short-circuit fault detection in closed-loop AC drives [PDF]

, 2013
This paper deals with an on-line method for turn-to-turn short-circuit fault detection in low-voltage permanent-magnet synchronous machine drives. Due to the closed-loop control, the fault effects are reflected in the voltage.
Johan Gyselinck, Gyselinck, Johan, KESTELYN, Xavier, Semail, Eric, Eric Semail, Yves Mollet, Meinguet, Fabien, Kestelyn, X., Mollet, Yves, Fabien Meinguet, Xavier Kestelyn   +10 more
core   +1 more source

Leakage reactance variation in dry-type transformers due to spacer positioning: A FEM and experimental study

Engineering Science and Technology, an International Journal
Leakage reactance is a fundamental electrical parameter in transformers that directly affects voltage regulation, efficiency, and short-circuit performance.
Kamran Dawood
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source