Results 31 to 40 of about 3,109,433 (263)

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola   +4 more
wiley   +1 more source

Microphysical Characteristics and Environmental Isotope Effects of the Micro-Droplet Groups under the Action of Acoustic Waves

open access: yesAtmosphere, 2021
Acoustics can cause particles/droplets to agglomerate in the air medium, thereby accelerating gravity sedimentation. To assess the microphysical characteristics and environmental isotope effects of micro-droplet groups under the action of acoustic waves,
Wenwen Bai   +4 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Encounter probability analysis of irrigation water and reference crop evapotranspiration in irrigation district

open access: yesJournal of Hydrology and Hydromechanics, 2018
Based on the data series of the annual reference crop evapotranspiration (ET0) and the amount of irrigation water (IR) from 1970 to 2013 in the Luhun irrigation district, the joint probability distribution of ET0 and IR is established using the Gumbel ...
Zhang Jinping, Li Jiayi, Shi Xixi
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Atmospheric Exploration of the Qinghai–Tibet Plateau during the East Asian Winter Monsoon (EAWM) from a Ground-Based Microwave Radiometer

open access: yesAtmosphere, 2022
The investigation of atmospheric characteristics is of great significance in properly exploiting air and water resources, and quantitatively estimating and nowcasting precipitation.
Yang Shi   +4 more
doaj   +1 more source

Energy and Water Balance at High Altitude [PDF]

open access: yesPhysiology, 2001
Many studies have shown that subjects lose significant amounts of body mass, fat mass as well as fat-free mass, during a climb to and/or a stay at high altitude. Altitude-induced weight loss is mainly caused by malnutrition due to hypoxia-related satiety, independent of acute mountain sickness.
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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