Results 61 to 70 of about 3,109,433 (263)

A numerical study of anchored sheet piles subjected to different types of sandy soils backfill

HBRC Journal, 2018
A numerical parametric study using the finite element program of PLAXIS was performed on single and double anchored sheet piles systems using different types of sandy soil backfill (loose, medium dense, and dense sand).
Dina A. Emarah, Safwat A. Seleem
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Dynamic estimation of maize leaf area index and improvement of critical nitrogen concentration curve based on multi-feature fusion of unmanned aerial vehicle images

Frontiers in Remote Sensing
Maize is an important food crop grown in the Yellow River irrigation area of Inner Mongolia. Its yield and quality are closely related to nitrogen nutrition status. Traditional nitrogen fertilizer management relies on empirical fertilization, which often
Shilong Miao, Shilong Miao, Xianyue Li, Xianyue Li, Haibin Shi, Haibin Shi, Jianwen Yan, Jianwen Yan, Shijie Ding, Shijie Ding   +9 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Long-term evolution patterns of groundwater depth and lagged response to precipitation in a complex aquifer system: Insights from Huaibei Region, China

Open Geosciences
The interaction mechanism model between shallow groundwater and precipitation.
Xu Yi, Xu Chengjuan, Liu Meng, Qian Xiaoxuan   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Unravelling microstructure evolution induced mechanical responses in welded joints of QN1803 steel subjected to varied heat inputs

Journal of Materials Research and Technology
In this work, QN1803 steel plates were connected with butt welding. Electron beam welding (EBW) was utilized with different beam currents. The impact of beam current on the properties and microstructure of the joints was investigated completely.
Xingxing Wang, Yuanlong Jiang, Honggang Dong, Jiahao Tian, Shuai Li, Kunming Pan, Zhipeng Yuan, Zicheng Ling, Xu Xie, Jianjun Shi   +9 more
doaj   +1 more source