Results 121 to 130 of about 2,566,078 (299)
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Higher-order reductions of the Mikhalev system [PDF]
We consider the 3D Mikhalev system, ut = wx, uy = wt − uwx + wux, which has first appeared in the context of KdV-type hierarchies. Under the reduction w = f(u), one obtains a pair of commuting first-order equations, ut = f′ux, uy = (f′2 − uf′ + f)ux ...
Vladimir Novikov (1259079) +2 more
core +2 more sources
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Higher-order modulation theory for resonant flow over topography [PDF]
, 2017 2017 Author(s). The flow of a fluid over isolated topography in the long wavelength, weakly nonlinear limit is considered. The upstream flow velocity is assumed to be close to a linear long wave velocity of the unforced flow so that the flow is near ...
Noel Smyth (20120784) +2 more
core
Ain Shams Engineering JournalThis study examines the analytic wave solutions of a fourth-order (2+1)-dimensional nonlinear Schrödinger equation with higher-order odd and even terms using the modified Sardar sub-equation method.
Noha M. Kamel +2 more
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Higher-order interpretations for higher-order complexity [PDF]
, 2017 International audienceWe design an interpretation-based theory of higher-order functions that is well-suited for the complexity analysis of a standard higher-order functional language à la ml. We manage to express the interpretation of a given program in
Hainry, Emmanuel, Péchoux, Romain
core +5 more sources
Electronic Journal of Differential Equations, 2018 In this article, we discuss the existence of positive solution to a nonlinear p-Laplacian fractional differential equation whose nonlinearity contains a higher-order derivative $$\displaylines{ D_{0^+}^{\beta}\phi_p\big(D_{0^+}^{\alpha}u(t)\big) +f ...
You-Hui Su +3 more
doaj
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source