Results 71 to 80 of about 347,643 (299)

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Tensor models, Kronecker coefficients and permutation centralizer algebras

Journal of High Energy Physics, 2017
We show that the counting of observables and correlators for a 3-index tensor model are organized by the structure of a family of permutation centralizer algebras.
Joseph Ben Geloun, Sanjaye Ramgoolam
doaj   +1 more source

Genealogy and clinical course of catecholaminergic polymorphic ventricular tachycardia caused by the ryanodine receptor type 2 P2328S mutation.

PLoS ONE, 2020
BackgroundCatecholaminergic polymorphic ventricular tachycardia (CPVT) is a severe inherited arrhythmic disease associated with a risk of syncope and sudden cardiac death (SCD).AimsWe aimed at identifying RYR2 P2328S founder mutation carriers and ...
Mikael Koponen, Annukka Marjamaa, Annukka M Tuiskula, Matti Viitasalo, Terhi Nallinmaa-Luoto, Jaakko T Leinonen, Elisabeth Widen, Lauri Toivonen, Kimmo Kontula, Heikki Swan   +9 more
doaj   +1 more source

An evaluation of excellence in primary healthcare units after the introduction of a performance management innovation in two regional states of Ethiopia: a facility based comparative study

BMC Health Services Research, 2022
Background The Ethiopian Ministry of Health strives to achieve universal health coverage (UHC) through increasing the number of its high-performing primary healthcare units. Although the Ethiopian health system is managed within a decentralized political
Wubishet Kebede Heyi, Elias Mamo Gurmamo, Amare Assefa Anara, Agegnehu Gebru Sendeku, Abera Refissa, Feyisa Serbessa Yadeta, Mesele Damte Argaw, Binyam Fekadu Desta   +7 more
doaj   +1 more source

The C∗-algebras of finitely aligned higher-rank graphs

Journal of Functional Analysis, 2004
We generalise the theory of Cuntz-Krieger families and graph algebras to the class of finitely aligned $k$-graphs. This class contains in particular all row-finite $k$-graphs. The Cuntz-Krieger relations for non-row-finite $k$-graphs look significantly different from the usual ones, and this substantially complicates the analysis of the graph algebra ...
Raeburn, Iain, Sims, Aidan, Yeend, Trent
openaire   +3 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Optimization and Application of Generative AI Algorithm Based on Transformer Architecture in Adaptive Learning

Information
At present, generative AI has problems of insufficient content generation accuracy, weak personalized response, and low reasoning efficiency in adaptive learning scenarios, which limit its in-depth application in intelligent teaching.
Xuan Liu, Zhi Li
doaj   +1 more source

Trends of cleft surgeries and predictors of late primary surgery among children with cleft lip and palate at the University College Hospital, Nigeria: A retrospective cohort study.

PLoS ONE, 2023
BackgroundCleft of the lip and palate is the most common craniofacial birth defect with a worldwide incidence of one in 700 live births. Early surgical repairs are aimed at improving appearance, speech, hearing, psychosocial development and avoiding ...
Afieharo Igbibia Michael, Gbenga Olorunfemi, Adeola Olusanya, Odunayo Oluwatosin   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source