Results 41 to 50 of about 7,501,853 (298)

Machine learning in coronary heart disease prediction: Structural equation modelling approach

open access: yesCogent Engineering, 2020
This research is an application of machine learning in medical sciences. The purpose of this research was to use machine learning through the simulated data to study the association of age, body mass index, cigarettes smoked per day, alcohol consumed per
Lewlyn L. R. Rodrigues   +7 more
doaj   +1 more source

Statistical Methods For Detecting Genetic Risk Factors of a Disease with Applications to Genome-Wide Association Studies [PDF]

open access: yes, 2015
This thesis aims to develop various statistical methods for analysing the data derived from genome wide association studies (GWAS). The GWAS often involves genotyping individual human genetic variation, using high-throughput genome-wide single ...
Ali, Fadhaa   +1 more
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Higher Education Earnings Premium: Value, Variation, and Trends [PDF]

open access: yes, 2014
Overall, people with a college education do better in the labor market than people with no education beyond high school. Higher levels of education correspond, on average, to higher levels of employment and higher wages.
Sandy Baum
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Financing Higher Education in Latin America [PDF]

open access: yes, 2014
Latin American countries have been enjoying a strong growth during the 2000s for the first time since the debt crisis of the 1980s. This article focuses on some of the changes that took place during these boom years with regard to public and private ...
Garcia, Ana Maria
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Pathways to Higher Education [PDF]

open access: yes, 2008
Presents case studies from Ford's initiative to support efforts to transform universities abroad to enable poor, minority, and otherwise underrepresented students to obtain a university degree.
Irma Rosa Martinez   +4 more
core  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

TANF and Higher Education [PDF]

open access: yes, 2010
Welfare reforms in 1996 created the Temporary Assistance for Needy Families Block Grant program (TANF). Under the assumption that a job will provide recipients with a path to self-sufficiency, this program focuses primarily on putting them to work ...
Hardy, Leah
core   +1 more source

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