Results 121 to 130 of about 2,513,833 (303)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

DDX-JK: a data-driven and explainable machine learning framework for reducing circuit simulation overhead in CMOS JK flip-flop designs

Discover Applied Sciences
Introduction Transistor count is a critical circuit-level metric, as it directly influences power consumption, propagation delay, leakage, and overall design complexity in VLSI systems.
Arjun Sunil Rao, R. Roopalakshmi, Samrat Sharma, Samana Nagendran, Prachita Singal, Aditi Javeri, Nandana Kamath, Adithya Sriraman   +7 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Marketing Strategy of Higher Education Institutions

Mediterranean Journal of Social Sciences, 2015
© 2015, Mediterranean Center of Social and Educational Research. All rights reserved. The article reveals the essence of the formation of the university's marketing strategy allows us to adapt to the requirements of the market. Also in the article shows the results of the analysis of motives in choosing profession and the university.
openaire   +4 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Significance of serum protein electrophoresis in diagnosing multiple myeloma: A retrospective study at a tertiary care centre

Indonesian Journal of Medical Laboratory Science and Technology
Multiple myeloma (MM) is a hematologic malignancy characterized by uncontrolled plasma cell proliferation in the bone marrow, initially asymptomatic, often causing symptoms like bone pain, anemia, renal dysfunction, and increased infection ...
Shrinidhi Sundar, Swetha Raghavendra Prasad , Dhivya Senthil Kumar, Sathya Selvarajan, Sowmya Krishnamurthy, Sridharan Kopula Sathyamurthy   +5 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Integrated Project Delivery (IPD) Research Trends. [PDF]

Journal of Engineering, Project, and Production Management, 2017
Integrated Project Delivery (IPD) is introduced as a vibrant approach to enhance project implementation, having particular position in recent studies among construction researchers.
Kahvandi, Z., Saghatforoush, E., Alinezhad, M., Noghli, F.   +3 more
doaj  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source