Results 61 to 70 of about 4,125,808 (289)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Higher Order Statistics in Switched Diversity Systems
CoRR, 2015 We analyze the level crossing rate (LCR) and the average fade duration of the output signal-to-noise-ratio (SNR) in generalized switched diversity systems. By using a common approach, we study these higher order statistics for two different kinds of configurations: (1) Colocated diversity, i.e.
Adrián Sauco-Gallardo +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
NeuroImageInferring chronological age from magnetic resonance imaging (MRI) brain data has become a valuable tool for the early detection of neurodegenerative diseases. We present a method inspired by cosmological techniques for analyzing galaxy surveys, utilizing
Aurelio Carnero Rosell +5 more
doaj +1 more source
IEEE Access, 2019 As one of the key techniques determining the overall system performances, efficient and reliable algorithms for improving the classification accuracy of motor imagery (MI) based electroencephalography (EEG) signals are highly desired for the development ...
Muhammad Tariq Sadiq +6 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Combining Higher-Order Statistics and Array Techniques to Pick Low-Energy P-Seismic Arrivals
Applied SciencesWe propose the HOSA algorithm to pick P-wave arrival times on seismic arrays. HOSA comprises two stages: a single-trace stage (STS) and a multi-channel stage (MCS). STS seeks deviations in higher-order statistics from background noise to identify sets of
Giovanni Messuti +6 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Statistics of Heat Transfer in Mesoscopic Circuits
, 2003 A method to calculate the statistics of energy exchange between quantum systems is presented. The generating function of this statistics is expressed through a Keldysh path integral.
A.A.M. Staring +29 more
core +2 more sources