Results 101 to 110 of about 149,713 (251)

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Bayesian inference for dependent stress–strength reliability of series–parallel system based on copula

Scientific Reports
In this paper, we investigate the inferential procedures for dependent stress-strength reliability within a series-parallel system, utilizing the Clayton copula to characterize the dependence structure between stress and strength variables, which follow ...
Li Zhang, Rongfang Yan, Junrui Wang
doaj   +1 more source

On the Decision-Theoretic Foundations and the Asymptotic Bayes Risk of the Region of Practical Equivalence for Testing Interval Hypotheses

Stats
Testing interval hypotheses is of huge relevance in the biomedical and cognitive sciences; for example, in clinical trials. Frequentist approaches include the proposal of equivalence tests, which have been used to study if there is a predetermined ...
Riko Kelter
doaj   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Frequentist and Bayesian Predictive Inference for the Log-Logistic Distribution Under Progressive Type-II Censoring

Entropy
This paper investigates the prediction of unobserved future failure times for the heavy-tailed Log-Logistic distribution under Progressive Type-II censoring.
Ziteng Zhang, Wenhao Gui
doaj   +1 more source

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Mert Sisman, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +9 more
wiley   +1 more source

Inferences for the GKME Distribution Under Progressive Type-I Interval Censoring with Random Removals and Its Application to Survival Data

Axioms
The analysis of lifetime data under censoring schemes plays a vital role in reliability studies and survival analysis, where complete information is often difficult to obtain. This work focuses on the estimation of the parameters of the recently proposed
Ela Verma, Mahmoud M. Abdelwahab, Sanjay Kumar Singh, Mustafa M. Hasaballah   +3 more
doaj   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

Analysis of the new complementary unit Weibull model from adaptive progressively type-II hybrid

AIP Advances
In this study, we look at some estimation issues for complementary unit Weibull distributions in the context of adaptive progressive type-II hybrid censoring.
Refah Alotaibi, Mazen Nassar, Ahmed Elshahhat   +2 more
doaj   +1 more source