Results 61 to 70 of about 136,484 (249)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Optimum nutrition of the pregnant ewe : a meta-analytic approach : a thesis presented in partial fulfillment of the requirements for the degree of Doctorate of Philosophy in Animal Science at Massey University, Manawatū, New Zealand [PDF]

, 2017
Formal systematic review guidelines and meta-analytic methods were used in the present study to achieve three main objectives. Firstly, literature on the effect of ewe nutrition during pregnancy on fetal and postnatal lamb growth was reviewed and effect ...
Roca Fraga, Fernando Javier
core  

Observational bounds on the cosmic radiation density

, 2007
We consider the inference of the cosmic radiation density, traditionally parameterised as the effective number of neutrino species N_eff, from precision cosmological data. Paying particular attention to systematic effects, notably scale-dependent biasing
, , Cirelli M, Cole S Sanchez A G Wilkins S, Davis T M, Friedland A Zurek K M Bashinsky S, G G Raffelt, Goobar A, Hannestad S, Hannestad S, Hannestad S, Hannestad S, Ichikawa K, J Hamann, Lewis A, Mangano G, S Hannestad, Seljak U, Viel M, Wood-Vasey W M, Y Y Y Wong   +20 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Bayesian inference for the Rayleigh distribution using ordered extreme k-records ranked set sampling with random sample sizes

Alexandria Engineering Journal
This study presents an enhanced framework for statistical inference and prediction of the Rayleigh distribution using ordered extreme k-records ranked set sampling with both fixed and random sample sizes.
Haidy A. Newer, Bader S Alanazi
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

MatCal: Open Source Bayesian 14C Age Calibration in Matlab

Journal of Open Research Software, 2016
The matcal function provides radiocarbon (14C) age calibration in Matlab using the Bayesian highest posterior density (HPD). The function produces a probability distribution function (PDF) of calibrated ages, as well as 1 sigma (68.27%) and 2 sigma (95 ...
Bryan C. Lougheed, Stephen P. Obrochta
doaj   +1 more source

Electron spin resonance of nitrogen-vacancy centers in optically trapped nanodiamonds

, 2012
Using an optical tweezers apparatus, we demonstrate three-dimensional control of nanodiamonds in solution with simultaneous readout of ground-state electron-spin resonance (ESR) transitions in an ensemble of diamond nitrogen-vacancy (NV) color centers ...
A. N. Cleland, Abbondanzieri, B. J. Aleman, Balasubramanian, Barth, Block, Bradac, Braun, Brites, Chang, Cuche, D. D. Awschalom, D. J. Christle, Duan, Ericsson, Gruber, Hall, Maletinsky, Maze, McGuinness, Neuman, Schoenfeld, Schrand, Svoboda, V. R. Horowitz, Yu   +25 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Optimal sampling and statistical inferences for Kumaraswamy distribution under progressive Type-II censoring schemes

Scientific Reports, 2023
In this paper, we study non-Bayesian and Bayesian estimation of parameters for the Kumaraswamy distribution based on progressive Type-II censoring. First, the maximum likelihood estimates and maximum product spacings are derived.
Osama E. Abo-Kasem, Ahmed R. El Saeed, Amira I. El Sayed   +2 more
doaj   +1 more source