Results 1 to 10 of about 21,396 (191)

Time course of cerebral oxygenation and cerebrovascular reactivity in Kyrgyz highlanders. A five-year prospective cohort study [PDF]

Frontiers in Physiology, 2023
Introduction: This prospective cohort study assessed the effects of chronic hypoxaemia due to high-altitude residency on the cerebral tissue oxygenation (CTO) and cerebrovascular reactivity.Methods: Highlanders, born, raised, and currently living above 2,
Matthias C. Luyken, Matthias C. Luyken, Paula Appenzeller, Paula Appenzeller, Philipp M. Scheiwiller, Philipp M. Scheiwiller, Mona Lichtblau, Mona Lichtblau, Maamed Mademilov, Maamed Mademilov, Aybermet Muratbekova, Aybermet Muratbekova, Ulan Sheraliev, Ulan Sheraliev, Ainura Abdraeva, Ainura Abdraeva, Nuriddin Marazhapov, Nuriddin Marazhapov, Talant M. Sooronbaev, Talant M. Sooronbaev, Silvia Ulrich, Silvia Ulrich, Konrad E. Bloch, Konrad E. Bloch, Michael Furian, Michael Furian   +25 more
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Positive selection in the genomes of two Papua New Guinean populations at distinct altitude levels [PDF]

Nature Communications
Highlanders and lowlanders of Papua New Guinea have faced distinct environmental stress, such as hypoxia and environment-specific pathogen exposure, respectively.
Mathilde André, Nicolas Brucato, Georgi Hudjasov, Vasili Pankratov, Danat Yermakovich, Francesco Montinaro, Rita Kreevan, Jason Kariwiga, John Muke, Anne Boland, Jean-François Deleuze, Vincent Meyer, Nicholas Evans, Murray P. Cox, Matthew Leavesley, Michael Dannemann, Tõnis Org, Mait Metspalu, Mayukh Mondal, François-Xavier Ricaut   +19 more
doaj   +2 more sources

Is nitric oxide a clue to endemic goitre in highlanders? [PDF]

Thyroid Research, 2023
Goitre is commonly caused by a lack of iodine in the diet. This condition is particularly prevalent in high-altitude areas where iodine deficiency is common.
Jon O. Lundberg, Eddie Weitzberg
doaj   +2 more sources

Sex differences in genotype frequency and the risk of polycythemia associated with rs13419896 and rs2790859 among Tibetan highlanders living in Tsarang, Mustang, Nepal [PDF]

Journal of Physiological Anthropology
Background Tibetan highlanders have adapted to hypoxic environments through genetic mechanisms that avoid hemoglobin concentration increases and prevent polycythemia.
Hiroaki Arima, Takayuki Nishimura, Sweta Koirala, Masayuki Nakano, Hiromu Ito, Tomo Ichikawa, Kishor Pandey, Basu Dev Pandey, Taro Yamamoto   +8 more
doaj   +2 more sources

Gut microbiome alterations in pulmonary hypertension in highlanders and lowlanders

ERJ Open Research, 2023
Background Alterations in the gut microbiota have been observed in patients with pulmonary hypertension (PH), though whether the roles of the gut microbiota in PH at different altitudes are the same is unknown.
Wenxue Dong, Lifeng Ma, Qiumin Huang, Xu Yang, Zhendong Mei, Mengmeng Kong, Zhonghan Sun, Zhiying Zhang, Jing Li, Jiaojiao Zou, Dandan Chen, Yuxiang Dai, Daxin Zhou, Yan Zheng, Longli Kang   +14 more
doaj   +1 more source

Circulating Microparticles Are Differentially Increased in Lowlanders and Highlanders with High Altitude Induced Pulmonary Hypertension during the Cold Season

Cells, 2022
The role of microparticles (MPs) and cold in high altitude pulmonary hypertension (HAPH) remains unexplored. We investigated the impact of long-term cold exposure on the pulmonary circulation in lowlanders and high-altitude natives and the role of MPs ...
Akylbek Sydykov, Aleksandar Petrovic, Abdirashit M. Maripov, Marija Gredic, Daniel Gerd Bermes, Nadira Kushubakova, Kubatbek Muratali Uulu, Christina Pilz, Meerim Cholponbaeva, Melis Duishobaev, Samatbek Satybaldyev, Nurgul Satieva, Argen Mamazhakypov, Meerim Sartmyrzaeva, Nazgul Omurzakova, Zhainagul Kerimbekova, Nursultan Baktybek, Cholpon Kulchoroeva, Oleg Pak, Lan Zhao, Norbert Weissmann, Sergey Avdeev, Leonid N. Maslov, Hossein Ardeschir Ghofrani, Ralph Theo Schermuly, Akpay S. Sarybaev, Djuro Kosanovic   +26 more
doaj   +1 more source

Pulmonary haemodynamic response to exercise in highlanders versus lowlanders

ERJ Open Research, 2021
The aim of the study was to investigate the pulmonary haemodynamic response to exercise in Central Asian high- and lowlanders. This was a cross-sectional study in Central Asian highlanders (living >2500 m) compared with lowlanders (living
Silvia Ulrich, Stéphanie Saxer, Michael Furian, Patrick R. Bader, Paula Appenzeller, Philipp M. Scheiwiller, Maamed Mademilov, Ulan Sheraliev, Felix Tanner, Talantbek M. Sooronbaev, Konrad E. Bloch, Mona Lichtblau   +11 more
doaj   +1 more source

Distinguishing feature of gut microbiota in Tibetan highland coronary artery disease patients and its link with diet

Scientific Reports, 2021
The prevalence of coronary artery disease (CAD) in Tibetan Highlanders is lower than that in plain-living individuals, but the mechanism still unclear. Gut microbiota (GM) disorder is considered one of the potential factors involved in the pathogenesis ...
Yulan Ma, Lulu Zhu, Zhijun Ma, Zhongshan Gao, Yumiao Wei, Youlu Shen, Lin Li, Xingli Liu, Ming Ren   +8 more
doaj   +1 more source

Phenotypic differences between highlanders and lowlanders in Papua New Guinea.

PLoS ONE, 2021
ObjectivesAltitude is one of the most demanding environmental pressures for human populations. Highlanders from Asia, America and Africa have been shown to exhibit different biological adaptations, but Oceanian populations remain understudied [Woolcock ...
Mathilde André, Nicolas Brucato, Sébastien Plutniak, Jason Kariwiga, John Muke, Adeline Morez, Matthew Leavesley, Mayukh Mondal, François-Xavier Ricaut   +8 more
doaj   +1 more source

Unique hemoglobin dynamics in female Tibetan highlanders

Tropical Medicine and Health, 2021
Background Tibetan highlanders have adapted to hypoxic environments through the development of unique mechanisms that suppress an increase in hemoglobin (Hb) concentration even in high-altitude areas.
Hiroaki Arima, Masayuki Nakano, Sweta Koirala, Hiromu Ito, Basu Dev Pandey, Kishor Pandey, Takayuki Wada, Taro Yamamoto   +7 more
doaj   +1 more source