Results 131 to 140 of about 449,112 (270)

Existentialism, Plays, Politics Highlight College Speaker Plans

open access: yes, 1964
From the Rice Thresher Archive, a collection of newspaper articles published in the student newspaper for Rice University.
Stark, Barbara
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Coacervation in systems chemistry

open access: yesCommunications Chemistry
Communications Chemistry is delighted to introduce a Collection of articles that combine coacervation with systems chemistry. Here, the Guest Editors of the Collection introduce the importance of research at the interface between these two topics and ...
Lorraine Leon   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Newspaper editorials and comment articles: a "cinderella" genre? [PDF]

open access: yes, 2007
The present article provides an introduction to the special issue of Revista Electrónica de Lingüística Aplicada (RAEL) which is devoted to the analysis of newspaper editorials and opinion articles written in English, Spanish and French.
Alonso Belmonte, Isabel
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Respecting State Judicial Articles

open access: yes, 1990
Differences in the establishment and empowerment of American judicial systems should trigger variations in the ways in which cases are handled and law is practiced.
Parness, Jeffrey A.
core  

Towards an infrastructure for semantic applications: Methodologies for semantic integration of heterogeneous resources [PDF]

open access: yes, 2006
As with many domains, information retrieval and knowledge management (IR/KM) in agriculture suffers from the problems of semantic heterogeneity, making it difficult for providers to disseminate their services effectively and for users to retrieve the ...
Sini, Margherita   +3 more
core  

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