Results 131 to 140 of about 13,575,187 (324)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Budget impact analysis of alternative strategies for initiating antiretroviral therapy in Nigeria

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences
The World Health Organization (WHO) has recently made recommendations for treating all Human Immunodeficency Virus (HIV/AIDS) patients irrespective of their immune status.
Halima B. Giwa
doaj   +1 more source

Highly active nanostructured CoS2/CoS heterojunction electrocatalysts for aqueous polysulfide/iodide redox flow batteries

Nature Communications, 2019
Aqueous polysulfide/iodide redox flow batteries are attractive for scalable energy storage due to their high energy density and low cost. However, their energy efficiency and power density are usually limited by poor electrochemical kinetics of the redox
Dui Ma, Bo Hu, Wenda Wu, Xi Liu, J. Zai, Chenyong Shu, Tsegaye Tadesse Tsega, Liwei Chen, Xuefeng Qian, T. L. Liu   +9 more
semanticscholar   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Quality of care, support and treatment services in Jharkhand’s Antiretroviral Therapy Center (ARTC): A mixed methods operational research

Journal of Family Medicine and Primary Care
Background: India has demonstrated an overall reduction of 57% in estimated annual new HIV infections. Assessing the quality of the ART Centers (ARTC) services would enable us to focus on the gaps and take necessary measures to provide high-quality ART ...
G. Jahnavi, Vinayagamoorthy Venugopal, Pratima Gupta, Rajesh Kumar, Saurabh Varshney   +4 more
doaj   +1 more source

Determinants of immunological failure among clients on the first line treatment with highly active antiretroviral drugs in Dar es Salaam, Tanzania

Asian Pacific Journal of Tropical Biomedicine, 2014
Objective: To determine socio-cultural, demographic and highly active antiretroviral therapy (HAART) program-related factors associated with immunological failure (IF) among clients on HAART in Dar es Salaam care and treatment clinics.
Anthony Kapesa, Daniel Magesa, Alexander William, John Kaswija, Jeremiah Seni, Cyprian Makwaya   +5 more
doaj   +1 more source

The bromodomain-containing protein Ibd1 links multiple chromatin related protein complexes to highly expressed genes in Tetrahymena thermophila

, 2018
Background: The chromatin remodelers of the SWI/SNF family are critical transcriptional regulators. Recognition of lysine acetylation through a bromodomain (BRD) component is key to SWI/SNF function; in most eukaryotes, this function is attributed to ...
Burtch, Alyson, Fillingham, Jeffrey, Garg, Jyoti, Gingras, Anne-Claude, Lambert, Jean-Philippe, Mudalige, Cristina Thuppu, Nabeel-Shah, Syed, Pearlman, Ronald E., Ponce, Marcelo, Saettone, Alejandro   +9 more
core   +1 more source

Therapy of highly active pediatric multiple sclerosis

Multiple Sclerosis, 2019
Objective: Study aims were to determine the frequency of highly active disease in pediatric multiple sclerosis (MS), the response to natalizumab (NTZ) and fingolimod (FTY) treatment, and the impact of current treatment modalities on the clinical course ...
P. Huppke, B. Huppke, D. Ellenberger, K. Rostásy, H. Hummel, W. Stark, W. Brück, J. Gärtner   +7 more
semanticscholar   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

A Crosstalk Between Periodontal Disease and Human Immunodeficiency Virus: Application of Artificial Intelligence and Machine Learning in Risk Assessment and Diagnosis—A Narrative Review

Dentistry Journal
Periodontal disease (PD) is an inflammatory condition caused by multiple periodontal pathogens, particularly those belonging to the Red Complex. Various risk factors influence the development of PD, including age, sex, socioeconomic status, ethnicity ...
Bhavyasri Gaddam, Leela Subhashini C. Alluri, Ihunna Amugo, Lemlem Berta, McKayla Butler, Shania Ferguson, Alexys Ferguson, Ethel Harris, Vladimir Berthaud, Siddharth Pratap, Qingguo Wang, Chethan Sampath, Zaid H. Khoury, Pandu R. Gangula   +13 more
doaj   +1 more source