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Highly Pathogenic Avian Influenza

, 2015
Highly pathogenic avian influenza is an acute respiratory infectious disease caused by some viral strains of avian influenza virus A. Its severity is highly diverse ranging from common cold-like symptoms to septicemia, shock, multiple organ failure, Reye syndrome, pulmonary hemorrhage, and other complications leading to death.
Lu, Puxuan, Zhao, Qingxia
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Evaluation of a commercial ELISA as alternative to plaque reduction neutralization test to detect neutralizing antibodies against SARS-CoV-2

Scientific Reports, 2022
High-throughput detection of neutralizing antibodies against SARS-CoV-2 presents a valuable tool for vaccine trials or investigations of population immunity.
Natalie Hofmann, Marica Grossegesse, Markus Neumann, Lars Schaade, Andreas Nitsche   +4 more
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Highly Pathogenic Avian Influenza

Journal of Disaster Research, 2011
The highly pathogenic avian influenza, H5N1 subtype, has been transmitted to humans in 15 countries in the world, with a significantly high fatality rate. The transmission to humans has been expanded. Since the virus was transmitted to humans for the first time in Hong Kong in 1997, the transmission of the virus from human to human has been limited ...
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Visualization of SARS-CoV-2 particles in naso/oropharyngeal swabs by thin section electron microscopy

Virology Journal, 2023
Background SARS-CoV-2 replicates efficiently in the upper airways of humans and produces high loads of virus RNA and, at least in the initial phase after infection, many infectious virus particles.
Michael Laue, Tobias Hoffmann, Janine Michel, Andreas Nitsche   +3 more
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Flexible upscaling of laboratory PCR testing capacity at the Robert Koch Institute during the SARS-CoV-2 pandemic

Virology Journal, 2023
Background Over the course of the COVID-19 pandemic, laboratories worldwide have been facing an unprecedented increase in demand for PCR testing because of the high importance of diagnostics for prevention and control of virus spread.
Eva Krause, Janine Michel, Andreas Puyskens, Natalie Hofmann, Thomas Rinner, Barbara Biere, Brigitte G. Dorner, Martin Skiba, Lars Schaade, Andreas Nitsche   +9 more
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Detection of Francisellaceae and the differentiation of main European F. tularensis ssp. holarctica strains (Clades) by new designed qPCR assays

BMC Microbiology
Background The zoonotic and highly infectious pathogen Francisella tularensis is the etiological agent of tularemia. Tularemia in humans is mainly caused by F. tularensis subspecies tularensis and holarctica, but Francisella species like F.
Kristin Köppen, Kerstin Rydzewski, Julia Zajac, Marwah Al-Senwi, Sema Evcimen, Darius Schulze, Daniela Jacob, Klaus Heuner   +7 more
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Global ubiquitination analysis reveals extensive modification and proteasomal degradation of cowpox virus proteins, but preservation of viral cores

Scientific Reports, 2018
The emergence of Variola virus-like viruses by natural evolution of zoonotic Orthopoxviruses, like Cowpox virus (CPXV), is a global health threat. The proteasome is essential for poxvirus replication, making the viral components interacting with the ...
Marica Grossegesse, Joerg Doellinger, Annemarie Fritsch, Michael Laue, Janett Piesker, Lars Schaade, Andreas Nitsche   +6 more
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Pathogenic Mechanism of a Highly Virulent Infectious Hematopoietic Necrosis Virus in Head Kidney of Rainbow Trout (Oncorhynchus mykiss) Analyzed by RNA-Seq Transcriptome Profiling [PDF]

, 2022
Jin-Woo Kim, Miyoung Cho, Jong-Won Lim, Hyeseong Choi, Suhee Hong   +4 more
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First Serological Evidence of Crimean-Congo Hemorrhagic Fever Virus and Rift Valley Fever Virus in Ruminants in Tunisia

Pathogens, 2021
Crimean-Congo hemorrhagic fever virus (CCHFV, Nairoviridae family) and Rift Valley fever virus (RVFV, Phenuiviridae family) are zoonotic vector-borne pathogens with clinical relevance worldwide.
Khaoula Zouaghi, Ali Bouattour, Hajer Aounallah, Rebecca Surtees, Eva Krause, Janine Michel, Aymen Mamlouk, Andreas Nitsche, Youmna M’ghirbi   +8 more
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Animal models for highly pathogenic emerging viruses

Current Opinion in Virology, 2013
Exotic and emerging viral pathogens associated with high morbidity and mortality in humans are being identified annually with recent examples including Lujo virus in southern Africa, Severe Fever with Thrombocytopenia Syndrome virus in China and a SARS-like coronavirus in the Middle East.
Safronetz, David, Geisbert, Thomas W, Feldmann, Heinz   +2 more
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