Results 31 to 40 of about 102,043 (157)

Survival Outcomes in Breast Cancer Patients With Metastatic Bone Disease

open access: yesWorld Journal of Surgery, Volume 49, Issue 12, Page 3326-3334, December 2025.
To evaluate the survival outcomes of breast cancer patients with metastatic bone disease and to assess whether these patients exhibit different prognoses compared to those with more extensive metastatic involvement. ABSTRACT Objective To evaluate the survival outcomes of breast cancer patients with metastatic bone disease and to assess whether these ...
Gerard J. Hill   +11 more
wiley   +1 more source

Anticipated Out‐Of‐Pocket Costs and Prostate Cancer Management Among Men With Commercial Insurance

open access: yesCancer Medicine, Volume 14, Issue 17, September 2025.
ABSTRACT Introduction Men with newly diagnosed prostate cancer often appropriately elect for either immediate treatment or conservative management. The out‐of‐pocket costs they face vary by management strategy, with immediate treatment often superseding those of conservative management, potentially influencing patient decisions.
Sarah Leick   +12 more
wiley   +1 more source

Colectomy and Neoplasia Outcomes of Patients With Ulcerative Colitis Receiving Golimumab: A Post‐Authorisation Safety Study Using the Spanish ENEIDA Registry

open access: yesPharmacoepidemiology and Drug Safety, Volume 34, Issue 8, August 2025.
ABSTRACT Purpose Golimumab (GLM), an anti‐tumour necrosis factor alpha (anti‐TNFα) agent, is indicated for moderate to severe ulcerative colitis (UC). This post‐authorisation safety study evaluated the risk of colectomy due to intractable disease and advanced colonic neoplasia (high‐grade dysplasia and/or colorectal cancer) under real‐world conditions ...
Eugeni Domènech   +42 more
wiley   +1 more source

Nightmares about Fossils: Spectral Children and Intergenerational Trauma in the Work of Hilary Mantel

open access: yes
This paper analyses the persistence and significance of the motif of the ‘spectral child’ in the work of British novelist Hilary Mantel and maps the political and ethical work it does there. From Mantel’s debut duology through to her critically acclaimed
Arnold, Lucy
core   +5 more sources

Historical Fiction and Hilary Mantel [PDF]

open access: yesInternational Journal of English Literature and Social Sciences, 2022
Gudala Parimala   +1 more
openaire   +1 more source

Allele‐Specific Editing of a Dominant SCN8A Epilepsy Variant Protects against Seizures and Lethality in a Murine Model

open access: yesAnnals of Neurology, Volume 96, Issue 5, Page 958-969, November 2024.
Objective Developmental and epileptic encephalopathies (DEEs) can result from dominant, gain of function variants of neuronal ion channels. More than 450 de novo missense variants of the sodium channel gene SCN8A have been identified in individuals with DEE. Methods We studied a mouse model carrying the patient Scn8a variant p.Asn1768Asp. An AAV‐PHP.eB
Wenxi Yu   +9 more
wiley   +1 more source

Association between multimorbidity and postoperative mortality in patients undergoing major surgery: a prospective study in 29 countries across Europe

open access: yesAnaesthesia, Volume 79, Issue 9, Page 945-956, September 2024.
Summary Background Multimorbidity poses a global challenge to healthcare delivery. This study aimed to describe the prevalence of multimorbidity, common disease combinations and outcomes in a contemporary cohort of patients undergoing major abdominal surgery.
STARSurg Collaborative   +5144 more
wiley   +1 more source

Profilicity and online safety legislation

open access: yesJournal of Law and Society, Volume 51, Issue 3, Page 367-389, September 2024.
Abstract This article applies the concept of profilicity to the emergence of online harms legislation. Grounded in social systems theory, profilicity designates a mode of self‐presentation prevalent in social media environments, though discernible in the growing number of situations where personal identity is mediated via a profile intended to be ...
BERNARD KEENAN
wiley   +1 more source

Practising “Cruel Optimism”: Eight Months on Ghazzah Street by Hilary Mantel

open access: yesCivitas. Studia z Filozofii Polityki, 2023
The essay “Practising ‘cruel optimism’: Eight Months on Ghazzah Street by Hilary Mantel” delves into Mantel’s novel through the lens of Berlant’s concept of cruel optimism. Berlant’s construct, rooted in the pursuit of conventional notions of a fulfilling existence, highlights the protagonists’ endeavors in Saudi Arabia as a postcolonial adventure ...
openaire   +1 more source

Long‐Term Downregulation of the Sodium Channel Gene Scn8a Is Therapeutic in Mouse Models of SCN8A Epilepsy

open access: yesAnnals of Neurology, Volume 95, Issue 4, Page 754-759, April 2024.
Objective De novo mutations of the voltage‐gated sodium channel gene SCN8A cause developmental and epileptic encephalopathy (DEE). Most pathogenic variants result in gain‐of‐function changes in activity of the sodium channel Nav1.6, poorly controlled seizures, and significant comorbidities.
Sophie F. Hill*   +5 more
wiley   +1 more source

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