Results 141 to 150 of about 493,470 (318)

Mutant glycyl-tRNA synthetase (Gars) ameliorates SOD1G93A motor neuron degeneration phenotype but has little affect on Loa dynein heavy chain mutant mice [PDF]

, 2009
Background: In humans, mutations in the enzyme glycyl-tRNA synthetase (GARS) cause motor and sensory axon loss in the peripheral nervous system, and clinical phenotypes ranging from Charcot-Marie-Tooth neuropathy to a severe infantile form of spinal ...
Antoni L. Andreu, Elizabeth M. C. Fisher, Francesca Achilli, Gareth T. Banks, Hazel P. Williams, J. Barney Bryson, Linda Greensmith, Ruth Chia, Virginie Bros-Facer   +8 more
core   +4 more sources

Bayesian Recursive and Structural Equation Models to Infer Causal Links Among Gait Visual Scores on Campolina Horses

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Gait visual scores are widely applied to horse breeding because they are a fast and easy phenotyping strategy, allowing the numeric interpretation of a complex biological process such as gait quality. However, they may suffer from subjectivity or high environmental influence.
Fernando Bussiman, Jennifer Richter, Jorge Hidalgo, Fabyano Fonseca e Silva, Ricardo Vieira Ventura, Rachel Santos Bueno Carvalho, Elisângela Chicaroni Mattos, José Bento Sterman Ferraz, Joanir Pereira Eler, Júlio Cesar de Carvalho Balieiro   +9 more
wiley   +1 more source

Musculoskeletal discipline science plan [PDF]

Life sciences research in the musculoskeletal discipline must identify possible consequences of weightlessness on this system, understand the mechanisms of these effects, and develop effective and operationally practical countermeasures to protect ...

core   +1 more source

Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G. [PDF]

, 2017
Neuromyelitis optica spectrum disorders (herein called NMO) is an inflammatory demyelinating disease of the central nervous system in which pathogenesis involves complement-dependent cytotoxicity (CDC) produced by immunoglobulin G autoantibodies ...
Verkman, Alan S, Yao, Xiaoming
core   +2 more sources

The locomotor ecology of wild western lowland gorillas: How does the largest ape exploit complex arboreal environments?

Journal of Anatomy, EarlyView.
When travelling and feeding in the canopy, the western lowland gorillas engaged in bipedal locomotion likely as a strategy to mitigate the risk of falling at the cost of increased energy expenditure. Abstract Western lowland gorillas are the largest and most sexually dimorphic ape that habitually exploits arboreal environments.
Charlotte A. King, Jackie Chappell, Martha M. Robbins, Robin H. Crompton, William I. Sellers, Susannah K. S. Thorpe   +5 more
wiley   +1 more source

Alterations in Muscle Mass and Contractile Phenotype in Response to Unloading Models: Role of Transcriptional/Pretranslational Mechanisms

Frontiers in Physiology, 2013
Skeletal muscle is the largest organ system in mammalian organisms providing postural control and movement patterns of varying intensity. Through evolution, skeletal muscle fibers have evolved into three phenotype clusters defined as a muscle unit which ...
Kenneth M Baldwin, Fadia eHaddad, Fadia eHaddad, Clay E Pandorf, Roland R Roy, Roland R Roy, Reggie V Edgerton, Reggie V Edgerton, Reggie V Edgerton, Reggie V Edgerton   +9 more
doaj   +1 more source

Spinal Progenitor-Laden Bridges Support Earlier Axon Regeneration Following Spinal Cord Injury. [PDF]

, 2018
Impact statementSpinal cord injury (SCI) results in loss of tissue innervation below the injury. Spinal progenitors have a greater ability to repair the damage and can be injected into the injury, but their regenerative potential is hampered by their ...
Anderson, Aileen J, Carlson, Mitchell A, Cummings, Brian J, Dumont, Courtney M, Munsell, Mary K, Shea, Lonnie D   +5 more
core   +1 more source

Hindlimb suspension‑induced cell apoptosis in the posterior parietal cortex and lateral geniculate nucleus: corresponding changes in c‑Fos protein and the PI3K/Akt signaling pathway.

Acta Neurobiologiae Experimentalis, 2018
Recent physiological studies indicate that weightlessness reliably alters ocular structure and function, as well as the ability to process visual‑spatial information.
Wei Huang, Chen Chen, Xu-feng Liu
semanticscholar   +1 more source

Women in space: A review of known physiological adaptations and health perspectives

Experimental Physiology, EarlyView.
Abstract Exposure to the spaceflight environment causes adaptations in most human physiological systems, many of which are thought to affect women differently from men. Since only 11.5% of astronauts worldwide have been female, these issues are largely understudied.
Millie Hughes‐Fulford, Danielle J. Carroll, Heather C. M. Allaway, Bonnie J. Dunbar, Aenor J. Sawyer   +4 more
wiley   +1 more source

Effect of calcitriol supplementation and tail suspension on serum biomarkers of bone formation in rats [PDF]

, 2015
BACKGROUND: Calcitriol is documented to cause significant increase in bone mass densitometry counteracting osteoporosis. Promising results of calcitriol supplementation in studies aiming space flight induced osteoporosis is little and the effect of this ...
Amir Khoshvaghti, Ensiyeh Nasli Esfahani, Farideh Razi, Mojtaba Rismanchi, Seyed Jafar Hashemian   +4 more
core   +1 more source