Results 251 to 260 of about 493,470 (318)

Hindlimb suspension reduces muscle regeneration

European Journal of Applied Physiology, 1998
Exposure of juvenile skeletal muscle to a weightless environment reduces growth and satellite cell mitotic activity. However, the effect of a weightless environment on the satellite cell population during muscle repair remains unknown. Muscle injury was induced in rat soleus muscles using the myotoxic snake venom, notexin.
Paul Mozdziak, Q. Truong, A. Macius, Edward Schultz   +3 more
openaire   +3 more sources

NOS‐dependent effects of plantar mechanical stimulation on mechanical characteristics and cytoskeletal proteins in rat soleus muscle during hindlimb suspension

The FASEB Journal, 2021
The study was aimed at investigating the mechanisms and structures which determine mechanical properties of skeletal muscles under gravitational unloading and plantar mechanical stimulation (PMS). We hypothesized that PMS would increase NO production and
S. Tyganov, E. Mochalova, I. Melnikov, I. Vikhlyantsev, A. Ulanova, K. Sharlo, T. Mirzoev, B. Shenkman   +7 more
semanticscholar   +1 more source

Models of disuse: a comparison of hindlimb suspension and immobilization

Journal of Applied Physiology, 1986
The effects of 1 and 2 wk of hindlimb suspension (HS) on rat skeletal muscle function were determined and the results compared with those obtained previously with hindlimb immobilization (HI). Both models of disuse (HS and HI) primarily affected slow-twitch muscle. Each decreased the isometric twitch duration in the slow-twitch soleus; however, the HS-
Fitts, Robert H., Metzger, Joseph Mark, Riley, Denise A., Unsworth, B. R.   +3 more
openaire   +4 more sources

To what extent is hindlimb suspension a model of disuse?

Muscle & Nerve, 1990
AbstractThe extent to which the remaining active or passive components of musclemechanical stress not associated with weightbearing are involved in preserving muscle morphological and functional characteristics in the rodent hindlimb suspension model is not known. Such information would be relevant to the construction of appropriate countermeasures for
Robin N. Michel, Phillip F. Gardiner
openaire   +3 more sources

Adaptation of bone and tendon to prolonged hindlimb suspension in rats

Journal of Applied Physiology, 1988
The rat hindlimb suspension model was used to ascertain the importance of ground reaction forces in maintaining bone and tendon homeostasis. Young female Sprague-Dawley rats were randomly assigned to either a suspended or a nonsuspended group. After 28 days, femur bones and patellar tendons were obtained for morphological and biochemical analyses ...
Roland R. Roy, S. L. Curwin, L. L. Lewis, D. M. Deluna, E. K. Alford, A. C. Vailas   +5 more
openaire   +3 more sources

Rat soleus muscle ultrastructure after hindlimb suspension

Journal of Applied Physiology, 1990
The aim of the present investigation was to determine, by quantitative electron microscopy, the effects of a 5-wk tail-suspension period on rat soleus muscle ultrastructure. A marked decline (-60%) in muscle mass occurred. The mean fiber cross-sectional area decreased to a greater extent (-75%) than the capillary-to-fiber ratio (-37%), leading to a ...
S. R. Kayar, B. Sempore, Dominique Desplanches, Hans-Heinrich Hoppeler, R. Flandrois   +4 more
openaire   +3 more sources

Hindlimb suspension increases insulin binding and glucose metabolism

Journal of Applied Physiology, 1988
After 28 days of hindlimb-suspension, insulin binding, 2-deoxy-D-glucose (2-DG) uptake, and glucose metabolism (glycolysis and glycogenesis) were determined at various insulin concentrations (0.2-30 nM) in soleus muscle of young (18-day-old) and adult (150-day-old) rats.
M. H. Tan, A. Bonen, G. C. Elder
openaire   +3 more sources

Intracranial Pressure Increases During Hindlimb Suspension

The FASEB Journal, 2016
IntroductionOne of the responses following exposure to the microgravity spaceflight environment is a pronounced cephalic fluid shift. Recent evidence documents ocular changes in astronauts following long‐duration missions including optic disc edema, globe flattening, choroidal folds and hyperopic shifts.
Heinrich S Gompf, Edward L. Robinson, Tana M. Hoban-Higgins, Charles A. Fuller   +3 more
openaire   +2 more sources

Ventral horn cell responses to spaceflight and hindlimb suspension

Journal of Applied Physiology, 1992
Spaceflight or hindlimb suspension results in a loss of mass and alterations of the metabolic and contractile protein profiles of skeletal muscles toward that resembling faster muscles. Given the influence of motoneurons on muscle properties, ventral horn cells of the lumbosacral enlargement of the spinal cord were studied to determine whether similar
I. B. Krasnov, I. V. Polyakov, V. R. Edgerton, Bian Jiang, Roland R. Roy   +4 more
openaire   +3 more sources

Single muscle fiber enzyme shifts with hindlimb suspension and immobilization

American Journal of Physiology-Cell Physiology, 1989
The purpose of this investigation was to determine how models of weightlessness, hindlimb suspension (HS), and hindlimb immobilization (HI) affect the metabolic enzyme profile in the slow oxidative (SO), fast oxidative glycolytic (FOG), and fast glycolytic (FG) fibers of rat hindlimb.
Fitts, Robert H., Brimmer, C. J., Heywood-Cooksey, Anne, Timmerman, R. J.   +3 more
openaire   +4 more sources