Results 261 to 270 of about 493,470 (318)

Contractile function of single muscle fibers after hindlimb suspension

Journal of Applied Physiology, 1989
The purpose of this investigation was to determine how muscle atrophy produced by the hindlimb suspension (HS) model alters the contractile function of slow- and fast-twitch single muscle fibers. After 2 wk of HS, small bundles of fibers were isolated from the soleus and the deep and superficial regions of the lateral and medial heads of the ...
Gardetto, P. R., Schluter, Jane Marie, Fitts, Robert H.   +2 more
openaire   +4 more sources

Pressure gradients and transport in the murine femur upon hindlimb suspension

Bone, 2006
Interstitial fluid flow (IFF) is important in a number of processes, including stimulation of cells and nutrient and waste transport. In bone, it arises from the vascular pressure gradient between the medullary cavity and the lymphatic drainage at the periosteal surface and is enhanced by mechanical loading events.
D.R. Meays, John A. Frangos, Hazel Y. Stevens   +2 more
openaire   +3 more sources

Hindlimb suspension diminishes femoral cross‐sectional growth in the rat

Journal of Orthopaedic Research, 1995
AbstractGrowth, functional adaptation, and torsional strength were examined in the femora of 39‐day‐old male Sprague‐Dawley rats subjected to hindlimb suspension for 0, 1, 2, 3, or 4 weeks and were compared with measurements for age‐matched control animals.
M.C.H. van der Meulen, Emily Morey-Holton, Dennis R. Carter, Dennis R. Carter   +3 more
openaire   +3 more sources

Structural and functional responses to prolonged hindlimb suspension in rat muscle

Journal of Applied Physiology, 1987
The purpose of this study was to investigate alterations in structural and functional properties in the soleus (SOL) and extensor digitorum longus (EDL) muscles of rats after 1, 2, and 5 wk of tail suspension. Maximal O2 uptake was 19% lower after 5 wk suspension. Loss of muscle mass was greater in SOL (63%) than in EDL (22%) muscle.
Dominique Desplanches, M. H. Mayet, B. Sempore, R. Flandrois   +3 more
openaire   +3 more sources

Development of patellofemoral osteoarthritis with knee joint malalignment and lateral patellar dislocation after hindlimb suspension in growing rats

Journal of Orthopaedic Research
Knee malalignment is a risk factor for patellar instability and patellofemoral osteoarthritis (PFOA), but etiologies remain unknown. We investigated the potential effects of decreased weight loading during growth on knee alignments and patellofemoral (PF)
J. Ozawa, Airi Ikeda, Marina Kanehara, Hideki Moriyama, A. Kaneguchi   +4 more
semanticscholar   +1 more source

Changes in stiffness induced by hindlimb suspension in rat Achilles tendon

European Journal of Applied Physiology, 2000
The aim of this study was to measure the effects of hindlimb suspension on mechanical properties of the rat Achilles tendon. Adult male Wistar rats were randomly assigned to groups to be either suspended, or a control. After 21 days, Achilles tendons were removed for mechanical analysis.
Maria I. Almeida-Silveira, Chantal Pérot, Francis Goubel, Daniel Lambertz   +3 more
openaire   +3 more sources

Interaction of compensatory overload and hindlimb suspension on myosin isoform expression

Journal of Applied Physiology, 1987
The purpose of this study was to investigate the role of chronic weight-bearing activity as the primary inducer of compensatory muscle growth and changes in myosin isoform expression in rodent fast-twitch plantaris muscle. Thus, female rats were subjected to the independent and simultaneous exposure of functional overload (induced via synergist ...
R. E. Herrick, Kenneth M. Baldwin, Richard W. Tsika   +2 more
openaire   +3 more sources

Restraint vs. hindlimb suspension on fluid and electrolyte balance in rats

Journal of Applied Physiology, 1996
To determine the effect of hindlimb suspension on body fluid volume, salt and water balance, and relevant hormones, two series of experiments were performed in an experimental protocol including periods of isolation (7 days), horizontal attachment (7 days), and suspension (14 days).
A. M. Allevard, L Somody, G. Gauquelin, Claude Gharib, F. Bouzeghrane, S. Fagette   +5 more
openaire   +3 more sources

UBE2D2 is not involved in MuRF1-dependent muscle wasting during hindlimb suspension.

The International Journal of Biochemistry & Cell Biology, 2016
The Ubiquitin Proteasome System (UPS) is mainly responsible for the increased protein breakdown observed in muscle wasting. The E3 ligase MuRF1 is so far the only enzyme known to direct the main contractile proteins for degradation (i.e. troponin I, myosin heavy chains and actin).
C. Polge, N. Koulmann, A. Claustre, M. Jarzaguet, B. Serrurier, L. Combaret, D. Béchet, X. Bigard, D. Attaix, D. Taillandier   +9 more
semanticscholar   +5 more sources

Effects of Growth hormone on rat skeletal muscle after hindlimb suspension [PDF]

European Journal of Applied Physiology and Occupational Physiology, 1994
To examine the effects of growth hormone (GH) on the preferential atrophy of the soleus muscle (SOL) occurring after hindlimb suspension (HS), two groups of male rats received daily injections of 2 IU.kg-1 body mass of recombinant human growth hormone (rhGH). Rats were either suspended by the tail for 21 days (HS-GH, n = 5) or nonsuspended (C-GH, n = 5)
A. X. Bigard, F. Lienhard, D. Merino, Charles-Yannick Guezennec, B. Serrurier   +4 more
openaire   +2 more sources