Results 141 to 150 of about 53,017 (247)

Cationic mRNA Lipid Nanoparticles for Ex Vivo NanoCAR‐T Cell Engineering

Advanced Science, EarlyView.
This study compares charge‑neutral and cationic lipidnanoparticles (LNPs) for ex vivo mRNA delivery to T cells, revealing distinctdependencies on medium composition and T cell activation. Where conventional LNPs benefit from ApoE‐dependent T cell targeting, cationic DOTAP‑modified LNPs mediate unspecific charge‑dependent transfection.
Laure Harinck, Stijn De Munter, Margo De Velder, Joline Ingels, Dominika Berdecka, Ine Lentacker, Winnok H. De Vos, Bart Vandekerckhove, Kevin Braeckmans, Koen Raemdonck   +9 more
wiley   +1 more source

The SMC Hinge is a Selective Gate for Obstacle Bypass. [PDF]

Nat Commun
Liu HW, Roisné-Hamelin F, Taschner M, Collier J, Srinivasan M, Gruber S.   +5 more
europepmc   +1 more source

Approaching Scarless Wound Healing: From Passive Anti‐Fibrotic to Proactive and Programmable Pro‐Regenerative Strategies

Advanced Science, EarlyView.
This review outlines the wound healing process and factors influencing scar formation, explores how certain animals and human fetuses achieve scarless skin or tissue regeneration, and details tissue engineering material strategies employed in scarless wound dressings.
Meimei Fu, Zhuoyi Huang, Jintao Li, Yue Li, Zhou Fang, Yiwen Jiang, Keke Wu, Jinshan Guo   +7 more
wiley   +1 more source

Transposable element-gene chimera cartography, origination and role in enhancing transcriptome plasticity. [PDF]

Nat Struct Mol Biol
Cheon Y, Alvstad EG, Torre D, Quach DT, Nguyen J, Hyun K, Zhou M, Yu T, Liu L, Yoon Y, Reese F, Faraone L, Li Y, Arnold FJ, Fstkchyan YS, Basu U, Kvon E, Valente EM, Ho JSY, Byun M, Guccione E, Shi Y, Weng Z, Seldin M, Marazzi I.   +24 more
europepmc   +1 more source

Deep Brain Stimulation Induces Antidepressant Effects by Restoring High‐Fidelity Communication in the BNST‐NAc Circuit

Advanced Science, EarlyView.
This cross‐species study reveals that pathological hyperactivity of BNST neurons in depressive states disrupts inhibitory period and isolated spikes in the BNST‐NAc circuit. DBS achieves its antidepressant effects by precisely restoring network inhibitory periods and high‐fidelity signal transmission.
Xin Lv, Yu Cao, Yuhan Wang, Yunhao Wu, Yingying Zhang, Kuanghao Ye, Xian Qiu, Qingfang Sun, Liuguan Bian, Halimureti Paerhati, Valerie Voon, Shikun Zhan, Bomin Sun   +12 more
wiley   +1 more source

Weight Loss During Obesity Provokes Asparaginase-Associated Liver Steatosis and Endoplasmic Reticulum Stress. [PDF]

FASEB J
Bhavsar CT, Zalma BA, Tomoo K, Zhang Y, Lopez EM, Mirek ET, Dixon JL, Henderson GC, Wek RC, Anthony TG.   +9 more
europepmc   +1 more source

Spectroscopic Evidence of Edge‐Localized States in an Antiferromagnet Topological Insulator NdBi

Advanced Science, EarlyView.
Using spin‐polarized scanning tunneling microscopy (STM) in conjunction with quasiparticle interference, we successfully identify distinct signatures of the ferromagnetic and antiferromagnetic terminations in NdBi, a rare‐earth monopnictide exhibiting non‐trivial topology and magnetism. We demonstrate that step edges on ferromagnetic surfaces host well‐
Avior Almoalem, Rebecca Chan, Brinda Kuthanazhi, Juan Schmidt, Jose A. Moreno, Hermann Suderow, Paul Canfield, Taylor L. Hughes, Vidya Madhavan   +8 more
wiley   +1 more source

Robotic posterior bar decalcification and mitral repair in mitral annular calcification. [PDF]

Ann Cardiothorac Surg
Loulmet DF, Hage A, Grossi EA.
europepmc   +1 more source

Emerging of Anomalous Higher‐Order Topological Phases in Altermagnet/Topological Insulator Heterostructure by Floquet Engineering

Advanced Science, EarlyView.
We combine altermagnet with topological insulators and subject the structure to Floquet driving. This breaks time‐reversal symmetry and creates a new type of higher‐order topological insulator. Its key feature is the emergence of programmable “0/π‐corner modes” that can be controlled by magnetic field direction, offering a novel dynamic platform for ...
Donghao Wang, Arnob Kumar Ghosh, Yongchun Tao, Fusheng Ma, Cheng Song   +4 more
wiley   +1 more source

A high signal-to-noise ratio and high-frequency seesaw cantilever for high-speed atomic force microscopy. [PDF]

Nat Commun
Li L, Miyagi A, Scheuring S.
europepmc   +1 more source