Results 171 to 180 of about 53,017 (247)

A Spatiotemporally Controlled Nanoplatform for Photothermal BRD4 Degradation Enables Synergistic Cancer Immunotherapy

Advanced Science, EarlyView.
A GSH‐responsive MOF nanoplatform acts as a Photothermolysis‐Targeting Conjugate (PTTAC). Through sophisticated step‐wise nuclear delivery, it enables NIR‐II light‐triggered photothermal degradation of BRD4. This precise strategy induces robust immunogenic cell death (ICD) and powerfully synergizes with anti‐PD‐L1 blockade to elicit a potent systemic ...
Luyi Wang, Jiasha Wu, Rui Ji, Sufeng Qiang, Yulin Shen, Yan Zuo, Shiqin Jian, Siyao Liu, Fusheng Xu, Honggang Hu, Xiaochun Hu   +10 more
wiley   +1 more source

A Polyaromatic Metallotube With a Dual Multi-Functionalization Ability. [PDF]

Angew Chem Int Ed Engl
Tagai K, Tanaka Y, Yamada M, Yoshizawa M.   +3 more
europepmc   +1 more source

Beyond the Non‐Hermitian Skin Effect: Scaling‐Controlled Topology from Exceptional‐Bound Bands

Advanced Science, EarlyView.
ABSTRACT We establish a novel mechanism for topological transitions in non‐Hermitian systems that are controlled by the system size. Based on a new paradigm known as exceptional‐bound (EB) band engineering, its mechanism hinges on the unique critical scaling behavior near an exceptional point, totally unrelated to the well‐known non‐Hermitian skin ...
Mengjie Yang, Ching Hua Lee
wiley   +1 more source

Advanced single-strut modelling of lightweight in-filled RC frames: validation and seismic performance assessment. [PDF]

Sci Rep
El-Fotuh GA, Attia WA, El-Feky MS.
europepmc   +1 more source

Endometrial Epithelial Lactate Deficiency Drives CD8+ T‐Cells Dysregulation in Unexplained Recurrent Implantation Failure

Advanced Science, EarlyView.
Unexplained recurrent implantation failure (RIF) represents a significant clinical challenge. Our results demonstrate that reduced lactate production in the RIF endometrium impairs the suppression of cytotoxic CD8+ T‑cells, allowing their proliferation and thereby disrupting the local immune balance essential for successful embryo implantation.
Yuanlin He, Kang Ke, Qingxia Meng, Yichun Guan, Jichun Tan, Hong Lv, Boxian Huang, Chan Tian, Qinyan Zou, Mingxing An, Yao Gao, Jingjing Chen, Xiaoyu Wei, Xi Wang, Hongxia Ma, Yuan Lin, Feiyang Diao, Yayun Gu, Zhibin Hu   +18 more
wiley   +1 more source

Multichamber magnetic capsule robot for selective liquid sampling and drug delivery. [PDF]

Natl Sci Rev
Wu Z, Wang X, Lu Y, Xu Q.
europepmc   +1 more source

Ultrahigh‐Linear Bio‐Inspired Janus Elastomeric Strain Sensor with High Sensitivity and Stretchability via Surface Wrinkle Engineering

Advanced Science, EarlyView.
A bio‐inspired Micro‐wrinkled Janus elastomeric flexible strain sensor mimicking wrinkled‐leaf viburnum is developed. Endowed with a synergistic sensing mechanism including wrinkle‐guided microcracks, modulus‐gradient‐driven strain division, and a parallel conductive circuit, it achieves ultra‐high linearity, sensitivity, wide strain range, and ...
Jing Lin, Ye Li, Simi Yu, Xing Cheng, Longxin Qian, Yufei Chen, Womin Li, Zhipeng Yang, Yinlei Lin, Dechao Hu, Jianyi Luo, Lan Liu   +11 more
wiley   +1 more source

Bacteria weigh up costs and benefits of mobile weapons. [PDF]

Elife
Wang Z, Fu Y.
europepmc   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Hinging Prejudices and Stereotypes in Mathematics. [PDF]

Topoi (Dordr)
Fairhurst J, Pérez-Escobar JA.
europepmc   +1 more source