Results 241 to 250 of about 1,740,260 (381)

A Resistive Soft Robotic Exosuit for Dynamic Body Loading in Hypogravity

open access: yesAdvanced Science, EarlyView.
The resistive hypogravity exosuit is a lightweight wearable robotic exosuit that uses pneumatic artificial muscles to restore Earth‐like metabolic and muscular demands during locomotion in low gravity. Tested on healthy subjects in Earth and simulated Moon gravity, the suit restores energy expenditure and muscle activation without altering gait ...
Emanuele Pulvirenti   +6 more
wiley   +1 more source

Training load and pain response during progressive resistance training in patients with hip osteoarthritis in the PROHIP trial. [PDF]

open access: yesOsteoarthr Cartil Open
Bryld ES   +6 more
europepmc   +1 more source

APOL2 Stabilizes Ku80 to Confer NHEJ‐Mediated Radioresistance in Gastric Cancer

open access: yesAdvanced Science, EarlyView.
Radiotherapy resistance in gastric cancer (GC) is often mediated by enhanced DNA repair. APOL2 is found to promote NHEJ by stabilizing Ku80, conferring radioresistance. High APOL2 correlates with poor prognosis. Formononetin disrupts APOL2‐Ku80, restoring radiosensitivity, suggesting a novel therapeutic strategy.
Dan Zu   +23 more
wiley   +1 more source

eIF4E Enriched Extracellular Vesicles Induce Immunosuppressive Macrophages through HMGCR‐Mediated Metabolic Rewiring

open access: yesAdvanced Science, EarlyView.
Here, it is revealed that ovarian cancer cells release extracellular vesicles enriched with eIF4E, which alters protein production in macrophages. This leads to increased expression of 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase (HMGCR), boosting cholesterol synthesis and activating an immunosuppressive pathway through X‐box binding protein 1 and ...
Sonam Mittal   +15 more
wiley   +1 more source

TWF2 Drives Tumor Progression and Sunitinib Resistance in Renal Cell Carcinoma through Hippo Signaling Suppression

open access: yesAdvanced Science, EarlyView.
Twinfilin actin‐binding protein (TWF2) is upregulated in sunitinib‐resistant renal cell carcinoma (RCC) cells, where it interacts with YAP and protects YAP from degradation. Stabilized YAP translocates into the nucleus and activates transcription of target genes, promoting RCC progression and drug resistance.
Liangmin Fu   +25 more
wiley   +1 more source

Variability in Physical Therapy Protocols After Hip Arthroscopy. [PDF]

open access: yesOrthop J Sports Med
Van Zyl J   +8 more
europepmc   +1 more source

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