Advanced Experiment Design Strategies for Drug Development
Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang +3 more
wiley +1 more source
Effect of spinal fusion length on hip and knee osteoarthritis: a comparative cohort study of no fusion, short-segment fusion, and long-segment fusion. [PDF]
Sülek Y +3 more
europepmc +1 more source
This article implements a unified human digital twin framework that integrates cutting edge actuation, sensing, simulation, and bidirectional feedback capability. The approach includes integrating multimodal sensing, AI, and biomechanical simulation into one compact system.
Tajbeed Ahmed Chowdhury +4 more
wiley +1 more source
Nodular Fasciitis of the Piriformis Muscle Initially Concerning for Metastasis in a Patient With Previous History of Colon Adenocarcinoma: A Case Report. [PDF]
Charles R +5 more
europepmc +1 more source
Holographic Mapping of Orbital Angular Momentum using a Terahertz Diffractive Optical Neural Network
A compact six‐layer diffractive optical neural network enables direct recognition and spatial mapping of terahertz (THz) orbital angular momentum (OAM) beams. Fabricated by 3D printing, the system distinguishes nine OAM modes and their superpositions with high fidelity, good efficiency, and low crosstalk, offering a scalable solution for THz ...
Wei Jia +3 more
wiley +1 more source
Perioperative Ketorolac Is Associated With Lower Mortality After Surgically Treated Hip Fracture in Older Adults. [PDF]
Perle SJ +5 more
europepmc +1 more source
EMG‐Driven Telemetry and Inference System for Fish: Pose Reconstruction and Flow Sensing
This work introduces an electromyography (EMG)‐driven telemetry framework that reconstructs body pose and infers hydrodynamic conditions in freely swimming fish. A custom 16‐channel archival system records intramuscular EMG, enabling deep‐learning models to decode joint kinematics, classify flow regimes, and reveal channel‐efficient sensing strategies.
Rahdar Hussain Afridi +7 more
wiley +1 more source
Bilateral Transient Osteoporosis of the Hip in Pregnancy: Diagnostic Challenges, MRI-Based Approach, and Multidisciplinary Management. [PDF]
Zubor P +5 more
europepmc +1 more source
Microfluidic Valve‐Integrated Garment for Smooth Sequential Gradient Mechanotherapy
We present a soft wearable sleeve that delivers smooth, gap‐free compression using overlapping air‐filled actuators and tiny microfluidic valves. The system reduces bulk, lowers power needs, and uses a smartphone‐sized control box. It can provide sequential gradient compression, gradient pressure holding, and fast deflation, supporting more portable ...
Run Ze Gao +5 more
wiley +1 more source
Early post-traumatic avascular necrosis with secondary osteoarthritis following an acetabular fracture in a 19-year-old patient treated with total hip arthroplasty: a case report. [PDF]
Khaiata H +4 more
europepmc +1 more source

