Results 201 to 210 of about 396,476 (287)

Cardiometabolic Risk in First Degree Relatives of Women With Polycystic Ovary Syndrome (PCOS)

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Objective Polycystic ovary syndrome (PCOS) is a common multisystem disorder with reproductive, cardiometabolic and psychological implications. Genetic factors play a role in the pathogenesis of PCOS. We sought to investigate the cardiometabolic health of first degree relatives (FDR) of women with PCOS.
Su Jen Chua   +8 more
wiley   +1 more source

A New Case of Lethal Congenital Contracture Syndrome Type 3 With Hyperinsulinism and Optic Atrophy

open access: yesClinical Genetics, EarlyView.
PIP5K1C‐related lethal congenital contracture syndrome with hyperinsulinism and optic atrophy. ABSTRACT Lethal congenital contracture syndrome 3 (LCCS3, MIM #611369) is a rare autosomal recessive neuromuscular disorder caused by biallelic loss‐of‐function (LOF) variants in PIP5K1C, reported in only two families to date.
Tameemi Abdalla Moady   +3 more
wiley   +1 more source

World Health Organization Healthy Ageing model applied to adults with cerebral palsy: A systematic review of reported intrinsic capacity measures

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
This systematic review reports on quantitative measures of intrinsic capacity domains of the WHO Healthy Ageing model for adults with CP. Reports from 102 studies showed reduced locomotor, vitality andn possibly cognitive intrinsic capacity reserves for adults aged 30–45 years.
Woroud Alzaher   +4 more
wiley   +1 more source

Disentangling the effect of brain insulin resistance on brain health (BIR‐BrainHealth): Rationale and study protocol

open access: yesDiabetic Medicine, EarlyView.
Abstract Aims Insulin signalling in the brain is crucial for systemic metabolic regulation and cognitive function. In some individuals, these effects are reduced, a phenomenon referred to as brain insulin resistance (BIR). This condition may contribute to the elevated risk of cognitive decline and dementia in diabetes, yet its prevalence, mechanisms ...
Sabrina Wangler   +11 more
wiley   +1 more source

The Evolving Landscape of Rectal Cancer Management—A Case for Centralisation?

open access: yes
ANZ Journal of Surgery, EarlyView.
Rathin Gosavi   +2 more
wiley   +1 more source

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