Results 41 to 50 of about 124,151 (316)

Pertrochanteric hip fracture is associated with mobility decline and poorer physical performance 4 to 6 months post-hip fracture

BMC Geriatrics, 2023
Background To study the effect of hip fracture type on physical performance, functional ability and change in mobility four to six months after the injury.
Minna A. Kujala, Markus T. Hongisto, Tiina Luukkaala, Sari Stenholm, Maria S. Nuotio   +4 more
doaj   +1 more source

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Advanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie, Meng Pan, Zeyuan Zhang, Licheng Zhang, Haotian Liu, Xia Wang, William W Lu, Peifu Tang, Wei Ge   +8 more
wiley   +1 more source

Associations of Quantitative and Qualitative Muscle Parameters With Second Hip Fracture Risk in Older Women: A Prospective Cohort Study

JBMR Plus, 2023
Older women with a first hip fracture exhibit heightened susceptibility and incidence of second fracture and potentially severe consequences. This prospective study was to compare the predictive power of qualitative and quantitative muscle parameters for
Wenshuang Zhang, Yufeng Ge, Yandong Liu, Yi Yuan, Jian Geng, Fengyun Zhou, Pengju Huang, Jia Shi, Kangkang Ma, Zitong Cheng, Glen M. Blake, Minghui Yang, Xinbao Wu, Xiaoguang Cheng, Ling Wang   +14 more
doaj   +1 more source

Epidemiology of Hip Fractures [PDF]

Epidemiologic Reviews, 1997
Hip fractures are the most serious osteoporotic fracture at both an individual and population level. In the United States alone there are over 250,000 hip fractures each year (1), costing at least 5.4 billion dollars annually (2). About 20 percent of persons who fracture their hip are dead within a year (3, 4) and, of the survivors, many never regain ...
Steven Cummings, Michael C. Nevitt, Robert G. Cumming   +2 more
openaire   +3 more sources

Dopamine D1 Receptor Contributes to Glucocorticoid‐Associated Osteonecrosis of Femoral Head Protection Through the ATF3/CHOP Axis to Inhibit Osteoblastic Apoptosis

Advanced Science, EarlyView.
This work identifies a novel mechanism by which dopamine D1 receptor (DRD1) contributes to the pathogenesis of glucocorticoid (GC)‐associated osteonecrosis of the femoral head (ONFH) through the regulation of osteoblastic apoptosis, indicating that DRD1 serves as a critical mediator of the crosstalk between the nervous and skeletal systems.
Kai Zheng, Wenming Li, Tianhao Wang, Gaoran Ge, Wei Zhang, Yi Qin, Wenhao Li, Zebin Wu, Zhen Wang, Gang Rui, Yaozeng Xu, Dechun Geng   +11 more
wiley   +1 more source

Targeting Hyperglycemic Bone Pre‐Metastatic Niche for Breast Cancer Bone Metastasis Therapy

Advanced Science, EarlyView.
This study reveals that breast cancer creates a hyperglycemic pre‐metastatic niche in bone prior to colonization and amplifies glucose metabolism post‐metastasis. To target this mechanism, a biomimetic enzyme‐engineered nanoplatform that disrupts tumor glycolytic pathways, proposing a therapeutic strategy to inhibit breast cancer bone metastasis by ...
Jianxin Ye, Peng Hu, Rui Zhang, Lei Zhou, Zonghua Luo, Yanan Chen, Shengzhe Ruan, Mengyi Zhu, Huaze Ding, Yike Qian, Yan Xing, Tong Meng, Changping Wang, Dianwen Song   +13 more
wiley   +1 more source

Ipsilateral Traumatic Posterior Hip Dislocation, Posterior Wall and Transverse Acetabular Fracture with Trochanteric Fracture in an adult: Report of First Case

Journal of Orthopaedic Case Reports, 2013
Introduction: Posterior dislocation of the hip joint with associated acetabular and intertrochanteric fracture is a complex injury. Early recognition, prompt and stable reduction is needed of successful outcome.
Skand Sinha, Ananta k Naik, Rajendra K Arya, Vijay K Jain   +3 more
doaj   +1 more source

Relationship Between Kyphosis and Postoperative Gastroesophageal Reflux After Proximal Gastrectomy

Annals of Gastroenterological Surgery, EarlyView.
This study examined the relationship between kyphosis and postoperative gastroesophageal reflux disease (GERD) after proximal gastrectomy using a kyphosis definition that is familiar to surgeons for preoperative assessment. Multivariate analysis revealed that kyphosis is an independent risk factor for GERD after proximal gastrectomy.
Takaomi Ozawa, Suguru Maruyama, Katsutoshi Shoda, Yoshihiko Kawaguchi, Ryo Saito, Kensuke Shiraishi, Shinji Furuya, Hidetake Amemiya, Hiromichi Kawaida, Daisuke Ichikawa   +9 more
wiley   +1 more source

Association of calf circumference with osteoporosis and hip fracture in middle-aged and older adults: a secondary analysis

BMC Musculoskeletal Disorders
Background Osteosarcopenia is a geriatric syndrome associated with an increased risk of frailty, falls, fractures, disability, and death. Calf circumference (CC) has been used as a simple and practical skeletal muscle marker to diagnose sarcopenia.
Mumin Cao, Yuanwei Zhang, Mengze Tong, Xiangxu Chen, Ziang Xu, Renwang Sheng, Liu Shi, Cheng Zhang, Wenbin Fan, Tian Xie, Yingjuan Li, Jinyu Wang, Wei Gao, Yunfeng Rui   +13 more
doaj   +1 more source

Ocular Findings as the Most Striking Manifestation of a SMAD3 Variant

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Loeys‐Dietz syndrome (LDS) is a heritable connective tissue disorder with variable expressivity. It is a multisystemic condition mainly characterized by a propensity for arterial aneurysms and dissections, skeletal manifestations, hypertelorism, bifid uvula, craniosynostosis, and cutaneous features.
Noémie Villeneuve‐Cloutier, Christie A Boswell‐Patterson, Lucas Bronicki, Krista M. Vincent, Kalin Wilk, Andrea C. Yu, Gail E. Graham, Julie Richer   +7 more
wiley   +1 more source