Results 81 to 90 of about 784,109 (316)

Gut Microbiota‐Derived Indole‐3‐Propionic Acid Alleviates Diabetic Osteoporosis Through Nrf2‐Mediated Ferroptosis Suppression

Advanced Science, EarlyView.
Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai, Qinyong You, Gao Si, Daole Hu, Ao Sun, Shilong Su, Ruideng Wang, Jixing Fan, Shan Gao, Tengjiao Zhu, Chun‐Li Song, Fang Zhou, Yang Lv   +12 more
wiley   +1 more source

Association of calf circumference with osteoporosis and hip fracture in middle-aged and older adults: a secondary analysis

BMC Musculoskeletal Disorders
Background Osteosarcopenia is a geriatric syndrome associated with an increased risk of frailty, falls, fractures, disability, and death. Calf circumference (CC) has been used as a simple and practical skeletal muscle marker to diagnose sarcopenia.
Mumin Cao, Yuanwei Zhang, Mengze Tong, Xiangxu Chen, Ziang Xu, Renwang Sheng, Liu Shi, Cheng Zhang, Wenbin Fan, Tian Xie, Yingjuan Li, Jinyu Wang, Wei Gao, Yunfeng Rui   +13 more
doaj   +1 more source

Expert Consensus on the Management of Obesity in Older Adults (2026 Edition)

AGING MEDICINE, EarlyView.
This graphical abstract summarizes a safety‐first framework for managing obesity in older adults, with attention to age, functional status, comorbidities, and sarcopenia risk. Key assessments include BMI, waist measures, body fat percentage, skeletal muscle mass, and comprehensive geriatric evaluation. Management prioritizes reducing visceral fat while
Qi Pan, Lixin Guo
wiley   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Ipsilateral Traumatic Posterior Hip Dislocation, Posterior Wall and Transverse Acetabular Fracture with Trochanteric Fracture in an adult: Report of First Case

Journal of Orthopaedic Case Reports, 2013
Introduction: Posterior dislocation of the hip joint with associated acetabular and intertrochanteric fracture is a complex injury. Early recognition, prompt and stable reduction is needed of successful outcome.
Skand Sinha, Ananta k Naik, Rajendra K Arya, Vijay K Jain   +3 more
doaj   +1 more source

Risk of fractures in patients with multiple sclerosis: a population-based cohort study. [PDF]

, 2012
OBJECTIVE: To examine the risk of fracture in patients with multiple sclerosis (MS) compared with population-based controls. METHODS: A population-based cohort study was performed in the Dutch PHARMO Record Linkage System (1998-2008). Patients with MS (n
Van Staa, Tjeerd; id_orcid, Uitdehaag, BMJ, van Staa, T.P., Vries, F. de, van Staa, TP, Vestergaard, P, Herings, R.M., Leufkens, HGM, de Vries, F, Herings, RM, Staa, TP van, Uitdehaag, B M J, Herings, R M C, Leufkens, H.G.M., Uitdehaag, B.M.J., Cooper, Cyrus, van Staa, Tjeerd P., Herings, Ron M. C., Leufkens, H.G., Bazelier, MT, Dobson, R, Uitdehaag, Bernard M. J., Bazelier, M.T., Leufkens, H G M, Leufkens, HG, Ramagopalan, S, Cooper, C., Herings, R.M.C., Leufkens, Hubertus G. M., Cooper, C, Uitdehaag, BM, Bazelier, M T, de Vries, F., van Staa, T-P, Vestergaard, P., Herings, RMC, Giovannoni, G, Bazelier, Marloes T., Uitdehaag, B.M., de Vries, F.; id_orcid   +39 more
core   +2 more sources

Irish Hip Fracture Database National Report 2017

, 2021
This report is testament to the commitment of all the participating hospitals to the Irish Hip Fracture Database (IHFD) and the focus on providing hip fracture patients with care that is aligned to international best practice standards.
The National Office of Clinical Audit (NOCA) (11202798), Emer Ahern (11203359), Conor Hurson (11203365), Aisling Connolly (11648018), Fionnola Kelly (11648019), The Irish Hip Fracture Database Governance Committee (11648025), Louise Brent (8382345)   +6 more
core   +1 more source

Severe Phenotype in an Indian Family With Progressive Pseudorheumatoid Arthropathy of Childhood

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Progressive pseudorheumatoid arthropathy of childhood (PPAC) is a rare autosomal recessive progressive condition that affects the cartilage of joints and bones. The symptoms of PPAC include stiffness of the joints, bony swelling of the toes and fingers, short stature, kyphosis, and muscle weakness.
Narinder Singh, Arpita Neogi, Liliane H. Gibbs, Jagdish Soni, Elizabeth Chao, Virginia Kimonis   +5 more
wiley   +1 more source

Zoledronic Acid in Reducing Clinical Fracture and Mortality after Hip Fracture.

, 2007
BACKGROUND: Mortality is increased after a hip fracture, and strategies that improve outcomes are needed. METHODS: In this randomized, double-blind, placebo-controlled trial, 1065 patients were assigned to receive yearly intravenous zoledronic acid (at a
Moore, K.A., Lyles, K.W., Boonen, S., Nordsletten, L., Abrams, K., Hodgson, P.K., Colón-Emeric, C.S., Recknor, C., Eriksen, E.F., Mesenbrink, P., Adachi, J.D., Pieper, C.F., Hyldstrup, L., Magaziner, J.S., Horowitz, Z., Orloff, J.J., Mautalen, C., Lavecchia, C., Zhang, J., for the HORIZON Recurrent Fracture, Trial   +19 more
core   +1 more source

Milestone Attainment in Young Children With Arthrogryposis Multiplex Congenita: Developmental Profile and Associated Factors

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Evidence on developmental milestones in children with arthrogryposis multiplex congenita (AMC) under the age of five is scarce. This multisite cross‐sectional study described developmental status and examined factors associated with milestone attainment in 143 children aged 0–66 months from a pediatric AMC Registry.
Ahlam Zidan, Sophia C. Pasia, Emmanouil Rampakakis, Reggie Hamdy, Frank Rauch, Lauren C. Hyer, Joel Lerman, Haluk Altiok, Krister Freese, Cary Mielke, Sarah B. Nossov, Philip F. Giampietro, Thania Ordaz‐Robles, Noémi Dahan‐Oliel   +13 more
wiley   +1 more source