Results 91 to 100 of about 657,288 (235)

A Review of the Literature and An Analysis of Mortality and Hospitalization Data to Examine Patterns of Injuries Among Canadian Seniors [PDF]

Injury is a major cause of morbidity and mortality among seniors in Canada, resulting in large personal and economic costs. However, despite the importance injuries play in the health of seniors, with the exception of falls, there has been relatively ...
Joan Lindsay, Vicki Torrance, Parminder Raina   +2 more
core  

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

Advanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang, Ziting Zhou, Nannan Xue, Jiasi Deng, Yuanyuan Zhou, Xinying Lv, Yuxuan Wang, Yi Zhang, Haotian Pan, Geyan Xu, Yinkun Tao, Mengran Li, Xin Cui, Hongyue Ma, Qian Wang, Zhigang Lu   +15 more
wiley   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Prevalence, Risk Factors, and Health Care Utilization for Injuries Among Canadian Seniors: An Analysis of 1994 National Population Health Survey [PDF]

Despite the impact injuries have on hospitalization and mortality, relatively little research has been conducted examining injuries among seniors that do not require hospitalizations.
Steven Dukeshire, Donna Toivonen, Joan Lindsay, Parminder Raina, Larry Chambers   +4 more
core  

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Associations Between Hip Pathology, Hip and Groin Pain, and Injuries in Hockey Athletes: A Clinical Commentary

International Journal of Sports Physical Therapy
Femoroacetabular impingement (FAI), particularly cam morphology, is highly prevalent among elite hockey athletes. Moreover, hip and groin pain has become a common issue in hockey, with approximately 50% of European professional athletes reported to ...
Matt Kelly, Josh Secomb
doaj   +1 more source

School Nurses on the Front Lines of Healthcare: Emergencies Associated With Sport and Physical Activities (Part 4)-The Assessment of Pediatric Shoulder and Hip Injuries Utilizing the "SPASMS" Mnemonic. [PDF]

NASN Sch Nurse, 2022
Brigham E, Olympia RP.
europepmc   +1 more source

Sports-related Hip Injuries

Sports-related injuries of the hip joint and surrounding structures are frequently encountered in athletes, encompassing a wide spectrum of osseous, intra-articular, and extra-articular pathologies. Early and accurate detection of typical injury patterns
Sutter, Reto; https://orcid.org/, Abel, Frederik; https://orcid.org/, Schmaranzer, Florian; https://orcid.org/   +2 more
core   +1 more source

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source

Management of gunshot wound-related hip injuries: A systematic review of the current literature. [PDF]

J Orthop, 2021
Tisnovsky I, Katz SD, Pincay JI, Garcia Reinoso L, Redfern JAI, Pascal SC, Wham BC, Naziri Q, Suneja N.   +8 more
europepmc   +1 more source