Results 111 to 120 of about 2,518,808 (388)

QSOX2‐Mediated Disulfide Bond Modification Enhances Tumor Stemness and Chemoresistance by Activating TSC2/mTOR/c‐Myc Feedback Loop in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
High QSOX2 enhances stemness, drug resistance, and metastasis of ESCC cells. QSOX2‐mediated disulfide bond modification activates mTOR/c‐Myc signaling. CAFs‐secreted IGF‐1 drives mTOR/c‐Myc/QSOX2 positive feedback loop. Combining Ebselen, rapamycin, and cisplatin induces tumor dormancy in mice.
Wo‐Ming Chen, Xiao‐Ping Zhang, Xiao Sun, Hai‐Cheng Liu, Yuan‐Yuan Yan, Xue Wei, Yu Liang, Yue Feng, Zhengjie Chen, Yongxu Jia, Chen Jiang, Qian Yan, Lei Li   +12 more
wiley   +1 more source

ARTHROPLASTY OF THE HIP JOINT

Australian Journal of Physiotherapy, 1956
Arthroplasty of the hip aims to provide a painless, freely mobile, and stable joint, and is usually carried out to improve the function of a hip which is both stiff and painful.
openaire   +2 more sources

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source

Patient Outcomes Following Hip and Knee Joint Replacement Surgery: Role of the Social and Physical Environment in Recovery [PDF]

, 2016
Osteoarthritis is a degenerative joint disease that affects over 27 million Americans (Centers for Disease Control & Prevention, 2014). Joint replacement surgery is often recommended for patients who do not respond to conventional medical treatment. Post-
Sampson, Brittany Anne
core   +1 more source

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Advanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie, Meng Pan, Zeyuan Zhang, Licheng Zhang, Haotian Liu, Xia Wang, William W Lu, Peifu Tang, Wei Ge   +8 more
wiley   +1 more source

Dynamic knee valgus kinematics and their relationship to pain in women with patellofemoral pain compared to women with chronic hip joint pain

Journal of Sport and Health Science, 2019
Background: Dynamic knee valgus (DKV) is an abnormal movement pattern visually characterized by excessive medial movement of the lower extremity during weight bearing.
Eric Schmidt, Marcie Harris-Hayes, Gretchen B. Salsich   +2 more
doaj  

Deciphering the Acetabular Labrum's Cellular Atlas: MDK Inhibition as a Novel Therapeutic Method for Developmental Dysplasia of the Hip

Advanced Science, EarlyView.
This study explores developmental dysplasia of the hip (DDH) by analyzing acetabular labrum abnormalities using single‐cell and spatial transcriptomics. Aberrant fibrocartilage stem cell proliferation is linked to DDH progression. Targeting the MK signaling pathway with a specific inhibitor effectively alleviates early DDH abnormalities, offering ...
Runze Yang, Huiling Liu, Minghao Ge, Dingyuan Zhang, Tianhao Xu, Lei Zhang, Yanlin Zhu, Shun Li, Jian Li, Xin Ma, Weili Fu   +10 more
wiley   +1 more source

Exeision of the Hip-Joint [PDF]

The American Journal of the Medical Sciences
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openaire   +1 more source

Critical Design Strategy of Thermogalvanic Hydrogels for Low‐Grade Heat Harvesting

Advanced Science, EarlyView.
This review highlights thermogalvanic hydrogels for efficient low‐grade heat harvesting, with a focus on design strategies. Key aspects include recent advances, thermoelectrochemical conversion mechanisms, performance metrics, enhancement approaches, and current device applications.
Wentao Lin, Shukai Wu, Shuo Niu, Zhe Hu, Guangming Chen, Zhuoxin Liu, Yang Huang, Chao Fang   +7 more
wiley   +1 more source

HUBUNGAN OBESITAS DENGAN RANGE OF MOTION SENDI PANGGUL DAN FLEKSI LUMBAL PADA DEWASA MUDA [PDF]

, 2016
Background : Obesity is a worldwide health problem that may be a risk factor for several diseases, including impaired mobility. Obesity is known as a factor that can affect the amount of the joints movement. However, there has been no study about obesity
Raharjo, Anita Sari Budi, Susanto, Hardono, Winarni, Tri Indah   +2 more
core   +1 more source