Results 271 to 280 of about 2,570,181 (406)

Advances in radiopharmaceuticals for cancer radiotheranostics: CCK2R targeting as a paradigm for translational innovation

open access: yesCancer Communications, EarlyView.
Abstract Radiopharmaceuticals are reshaping the landscape of cancer therapy, offering a unique theranostic advantage that is becoming increasingly central to precision medicine. By labeling the same molecular scaffold with different radionuclides, these agents enable seamless integration of diagnostic imaging and targeted therapy.
Jing Li   +6 more
wiley   +1 more source

Functional regression with intensively measured longitudinal outcomes: a new lens through data partitioning

open access: yesCanadian Journal of Statistics, EarlyView.
Abstract Modern longitudinal data from wearable devices consist of biological signals at high‐frequency time points. Distributed statistical methods have emerged as a powerful tool to overcome the computational burden of estimation and inference with large data, but methodology for distributed functional regression remains limited.
Cole Manschot, Emily C. Hector
wiley   +1 more source

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu   +21 more
wiley   +1 more source

Subsequent Total Joint Arthroplasty After Primary Total Knee or Hip Arthroplasty: A 40-Year Population-Based Study

open access: yesJournal of Bone and Joint Surgery. American volume, 2017
Thomas L Sanders   +4 more
semanticscholar   +1 more source

Quantitative Model‐Informed Dose Selection for a Milvexian Phase III Study in Patients With Atrial Fibrillation

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Milvexian, an activated factor XI inhibitor, is being evaluated in the LIBREXIA phase III program for the prevention of thrombotic events, including in patients with atrial fibrillation (LIBREXIA AF). To guide the selection of a phase III dose regimen for LIBREXIA AF, two main approaches were used: (1) population pharmacokinetics and exposure–response ...
Wangda Zhou   +12 more
wiley   +1 more source

Hip joint and age relationship in Thai population by image processing technique. [PDF]

open access: yesAnat Cell Biol
Krudtong S   +5 more
europepmc   +1 more source

Pathogenesis and potential therapeutic targets of trichorhinophalangeal syndrome; lessons obtained from animal studies

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Trichorhinophalangeal syndrome (TRPS) is a rare genetic disease inherited in an autosomal dominant manner. It occurs in 1 in 100,000 people globally and is caused by several types of mutations of the TRPS1 gene. Since the first human patient was reported in 1966, typical and atypical pathologies, disease courses, and treatment case ...
Naoya Saeki   +6 more
wiley   +1 more source

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