Results 101 to 110 of about 90,972 (303)

PIP5K1A Suppresses Ferroptosis and Induces Sorafenib Resistance by Stabilizing NRF2 in Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
Inducing ferroptosis is a promising strategy for combating tumor resistance. Upregulated PIP5K1A competes with NRF2 for KEAP1 binding, which decreases the ubiquitination degradation of NRF2 and promotes its nuclear translocation, thereby suppressing ferroptosis, and ultimately driving hepatocellular carcinoma (HCC) tumorigeneses and sorafenib ...
Mengzhou Guo   +9 more
wiley   +1 more source

Targeting Hyperglycemic Bone Pre‐Metastatic Niche for Breast Cancer Bone Metastasis Therapy

open access: yesAdvanced Science, EarlyView.
This study reveals that breast cancer creates a hyperglycemic pre‐metastatic niche in bone prior to colonization and amplifies glucose metabolism post‐metastasis. To target this mechanism, a biomimetic enzyme‐engineered nanoplatform that disrupts tumor glycolytic pathways, proposing a therapeutic strategy to inhibit breast cancer bone metastasis by ...
Jianxin Ye   +13 more
wiley   +1 more source

Aspirin-Persantin Prophylaxis in Elective total hip Replacement [PDF]

open access: bronze, 1977
Arthur J. Silvergleid   +5 more
openalex   +1 more source

Deciphering the Acetabular Labrum's Cellular Atlas: MDK Inhibition as a Novel Therapeutic Method for Developmental Dysplasia of the Hip

open access: yesAdvanced Science, EarlyView.
This study explores developmental dysplasia of the hip (DDH) by analyzing acetabular labrum abnormalities using single‐cell and spatial transcriptomics. Aberrant fibrocartilage stem cell proliferation is linked to DDH progression. Targeting the MK signaling pathway with a specific inhibitor effectively alleviates early DDH abnormalities, offering ...
Runze Yang   +10 more
wiley   +1 more source

Letter: Risks of total hip replacement. [PDF]

open access: bronze, 1975
Neil Shaw, Marianne Johnstone
openalex   +1 more source

Bioinspired Intelligent Soft Robotics: From Multidisciplinary Integration to Next‐Generation Intelligence

open access: yesAdvanced Science, EarlyView.
Soft robotics, featuring intrinsic compliance and biomimetic adaptability, emerges as transformative in next‐generation intelligent systems. This review outlines how advancements in four foundational domains—actuation, materials, manufacturing, and control—drive the evolution of bioinspired intelligent soft robotics, poised to redefine the boundaries ...
Xiaopeng Wang   +7 more
wiley   +1 more source

Late infection after hip replacement. [PDF]

open access: green, 1977
Roger Bayston, R.B. Zachary
openalex   +1 more source

Scalable and Integrated Photocatalytic Reactor Systems for Solar‐to‐Fuel Production: Photoredox and Photoreforming Processes

open access: yesAdvanced Energy Materials, EarlyView.
Solar fuels and other value‐added chemicals derived from light‐driven reactions are highly desirable. Although advanced photoactive materials have been reported, demonstrations of their feasibility in large‐scale production are needed. Hence, strategies and recent efforts in scaling up photocatalytic reactors and integrating them into comprehensive ...
Hoi Ying Chung   +5 more
wiley   +1 more source

The Effect of Immersion Technology on the Quality of Life in Older Adults: A Systematic Review

open access: yesAGING MEDICINE, EarlyView.
Immersive technologies, especially virtual reality (VR), significantly improve the quality of life for older adults by enhancing physical health, cognitive function, and psychological well‐being. These technologies can be adapted to meet individual needs, making them an effective tool for addressing the challenges of aging.
Solmaz Sohrabei   +2 more
wiley   +1 more source

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