Results 111 to 120 of about 3,151,327 (403)

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source

Is decreasing mortality in total hip and knee arthroplasty patients dependent on patients’ comorbidity?: A Danish nationwide, population-based cohort study (1996–2013)

Acta Orthopaedica, 2017
Background and purpose — Mortality after primary total hip and knee arthroplasty (THA and TKA) has declined, and the proportion of THA and TKA patients with comorbid conditions has increased.
Eva N Glassou, Alma B Pedersen, Torben B Hansen   +2 more
doaj   +1 more source

Impact of timing of surgery in elderly hip fracture patients: a systematic review and meta-analysis

Scientific Reports, 2018
We aimed to assess the impact of timing of surgery in elderly patients with acute hip fracture on morbidity and mortality. We systematically searched MEDLINE, the Cochrane Library, Embase, PubMed, and trial registries from 01/1997 to 05/2017, as well as ...
T. Klestil, C. Röder, C. Stotter, Birgit Winkler, S. Nehrer, M. Lutz, I. Klerings, G. Wagner, G. Gartlehner, B. Nussbaumer-Streit   +9 more
semanticscholar   +1 more source

Pre- and Post-Surgery analysis of functional capacity and quality of life of patienst with Osteoarthritis submitted to Total Hip Artroplasty [PDF]

, 2004
OBJECTIVE: To evaluate the functional capacity of the hip articulation and the quality of life of patients with osteoarthritis submitted to total artroplasty.
Patrizzi, Lislei Jorge, Takata, Edmilson Takehiro, Trigueiro, Gustavo, Vilaça, Karla Helena Coelho   +3 more
core   +2 more sources

METTL3/ALKBH5‐Mediated N6‐Methyladenosine Modification Drives Macrophage M1 Polarization via the SLC15A3‐TASL‐IRF5 Signaling Axis in Psoriasis

Advanced Science, EarlyView.
m6A modification stabilizes Slc15a3 mRNA in macrophages, activating the SLC15A3‐TASL‐IRF5 axis and promoting psoriatic inflammation. Abstract Impaired N6‐methyladenosine (m6A) modification has been implicated in regulating various inflammatory diseases, but its role in psoriasis remains unclear.
Tao Huang, Shijun Chen, Ke Ding, Liyan Yuan, Weiqi Lv, Kechen Chen, Yuchen Liu, Dongzhao Ma, Xin Zhang, Xiaobo Wang, Guanzheng Luo, Bin Yang, Ying Lin, Zhili Rong   +13 more
wiley   +1 more source

Implementation of outpatient hip and knee arthroplasty in a multicenter public healthcare setting

Acta Orthopaedica
Background and purpose: Length of hospital stay after hip and knee arthroplasty is about 1 day in Denmark with few patients discharged on the day of surgery.
Oddrún Danielsen, Claus Varnum, Christian Bredgaard Jensen, Thomas Jakobsen, Mikkel Rathsach Andersen, Manuel Josef Bieder, Søren Overgaard, Christoffer Calov Jørgensen, Henrik Kehlet, Kirill Gromov, Martin Lindberg-Larsen   +10 more
doaj   +1 more source

Predictors of Outcomes After Hip Arthroscopic Surgery for Femoroacetabular Impingement: A Systematic Review

Orthopaedic Journal of Sports Medicine, 2019
Background: The benefits of hip arthroscopic surgery in the setting of femoroacetabular impingement (FAI) have been well established; however, some patients may experience a greater degree of improvement than others.
Olawale A. Sogbein, Ajay Shah, J. Kay, M. Memon, N. Simunovic, E. Belzile, O. Ayeni   +6 more
semanticscholar   +1 more source

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Advanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie, Meng Pan, Zeyuan Zhang, Licheng Zhang, Haotian Liu, Xia Wang, William W Lu, Peifu Tang, Wei Ge   +8 more
wiley   +1 more source

Association of Duration of Surgery With Postoperative Delirium Among Patients Receiving Hip Fracture Repair

JAMA Network Open, 2019
Key Points Question Is surgery duration associated with postoperative delirium in patients receiving hip fracture repair? Findings In this population-based cohort study of 68 131 adults, increasing surgery duration was associated with a higher risk ...
B. Ravi, D. Pincus, Stephen Choi, R. Jenkinson, D. Wasserstein, D. Redelmeier   +5 more
semanticscholar   +1 more source

Complications of Resection Arthroplasty in Two-Stage Revision for the Treatment of Periprosthetic Hip Joint Infection [PDF]

, 2019
Little data is available regarding complications associated with resection arthroplasty in the treatment of hip periprosthetic joint infection (PJI). We assessed complications during and after two-stage revision using resection arthroplasty.
Perka, Carsten, Renz, Nora, Sigmund, Irene K., Trampuz, Andrej, Winkler, Tobias, Önder, Nuri   +5 more
core   +1 more source