Results 281 to 290 of about 3,151,327 (403)

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu   +21 more
wiley   +1 more source

The role of the PTHrP/Ihh feedback loop in the unusual growth plate location in mammalian metatarsals and pisiforms

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background Longitudinal skeletal growth takes place in the cartilaginous growth plates. While growth plates are found at either end of conventional long bones, they occur at a variety of locations in the mammalian skeleton. For example, the metacarpals and metatarsals (MT) in the hands and feet form only a single growth plate at one end, and ...
Philip L. Reno   +4 more
wiley   +1 more source

Dynamics of postnatal bone development and epiphyseal synostosis in the caprine autopod

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background Bones develop to structurally balance strength and mobility. Bone developmental dynamics are influenced by whether an animal is ambulatory at birth. Precocial species, which are ambulatory at birth, develop advanced skeletal maturity in utero and experience postnatal development under mechanical loading.
Christopher J. Panebianco   +8 more
wiley   +1 more source

Pericapsular Nerve Group (PENG) Block Versus Lumbar Erector Spinae Plane Block (ESPB) in Pediatric Hip Surgery: A Randomized, Double-Blinded, Controlled Trial. [PDF]

open access: yesJ Pediatr Orthop
Reysner M   +7 more
europepmc   +1 more source

Smartphone‐Supported Cognitive‐Behavioral Therapy in Binge‐Eating Disorder: An Exploratory Randomized Trial

open access: yesInternational Journal of Eating Disorders, EarlyView.
ABSTRACT Objective To assess the feasibility of a smartphone app delivering just‐in‐time adaptive interventions as an adjunct to cognitive‐behavioral therapy (CBT) adapted to binge‐eating disorder (BED), estimate its effects assuming superiority over CBT alone, and document safety and target engagement.
Anja Hilbert   +4 more
wiley   +1 more source

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