Results 211 to 220 of about 81,056 (343)

Synaptic ultrastructural alterations in human focal cortical dysplasia: Insights from volume electron microscopy

Epilepsia, EarlyView.
Abstract Objective Focal cortical dysplasia (FCD) is a developmental malformation of the cerebral cortex and a leading cause of drug‐resistant epilepsy in children and young adults. Disruption of the excitation–inhibition (E–I) balance is a hallmark of neuronal hyperexcitability in FCD, yet the underlying synaptic ultrastructural changes remain poorly ...
Gyu Hyun Kim, Na‐Young Seo, Seung‐Ki Kim, Jae‐Kyung Won, Yang Hoon Huh, Ji Yeoun Lee, Kea Joo Lee   +6 more
wiley   +1 more source

Case Report: Anti-SOX1 antibody-associated limbic encephalitis with hippocampal sclerosis: the first autopsy case. [PDF]

Front Immunol
Izumi R, Hayashi K, Kawahara E, Miki Y, Wakabayashi K, Suzuki A, Nakaya Y, Takaku N, Sato M, Horiuchi Y, Enomoto S, Kitazaki Y, Hamano T, Kobayashi Y.   +13 more
europepmc   +1 more source

Potassium–chloride cotransporter 2 activity dampens induced ictal‐like activity in neocortical slices containing the seizure propagation zone of temporal lobe epilepsy patients

Epilepsia, EarlyView.
The K⁺/Cl− cotransporter (KCC2) limits induced ictal‐like events and their spread in the supragranular layer of human neocortical slices from the seizure‐propagation zone of temporal lobe epilepsy patients. Cl⁻ extrusion is present in supragranular pyramidal neurons but limited under high somatic Cl⁻ load.
Alice Falck, Janna Lehnhoff, Mahraz Behbood, Egor Byvaltcev, Annette Aigner, Helena Radbruch, Pawel Fidzinski, Jan‐Hendrik Schleimer, Gabriel M. S. Janach, Noah Döhne, Julia Onken, Thilo Kalbhenn, Thomas Sauvigny, Rudolf A. Deisz, Susanne Schreiber, Martin Holtkamp, Ulf Strauss   +16 more
wiley   +1 more source

Chronic reduction of synaptic proteins in the epileptogenic lesion of patients with hippocampal sclerosis. [PDF]

Front Mol Neurosci
Oota-Ishigaki A, Suzuki N, Iijima K, Takayama Y, Kimura Y, Hattori K, Iwasaki M, Hayashi T.   +7 more
europepmc   +1 more source

Interhemispheric asymmetrical change in gray matter volume in patients with unilateral hippocampal sclerosis. [PDF]

J Clin Imaging Sci, 2023
Mugikura S, Mori N, Gang M, Kanno S, Jin K, Osawa SI, Nakasato N, Takase K.   +7 more
europepmc   +1 more source

Long‐term memory trajectories in seizure‐free patients following epilepsy surgery for hippocampal sclerosis

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to study long‐term memory trajectories over the years in patients with temporal lobe epilepsy and unilateral hippocampal sclerosis (TLE/HS) seizure‐free since surgery. Methods This cross‐sectional study included patients with TLE/HS from a single‐center epilepsy surgery program who had been seizure‐free for ...
William Alves Martins, Roberta Gomes, Eduardo Leal‐Conceição, Wyllians Vendramini Borelli, Rafael Paglioli, Thomas More Frigeri, Mirna Portuguez, Eliseu Paglioli, Andre Palmini   +8 more
wiley   +1 more source

Genome-wide association studies of TDP-43 proteinopathy and hippocampal sclerosis reveal shared genetic associations with APOE and TMEM106B. [PDF]

Alzheimers Dement
Godrich D, Pasteris J, Martin ER, Kunkle B, Naj AC, Hamilton K, Wang H, Lee WP, Dumitrescu L, Hohman TJ, Mayeux R, Larson EB, Crane PK, Keene CD, Latimer C, Mukherjee S, Kofler J, Kamboh MI, Bennett DA, Molina-Porcel L, Schellenberg G, Pericak-Vance MA, Cuccaro M, Scott WK, Rundek T, Kukull W, Montine T, Beecham GW, Alzheimer's Disease Genetics Consortium (ADGC).   +28 more
europepmc   +1 more source

Focal Cortical Dysplasia with hippocampal sclerosis. [PDF]

Autops Case Rep, 2023
Jadav D, Gupta V, Khera S, Meshram V.
europepmc   +1 more source

Somatic variants as a cause of drug-resistant epilepsy including mesial temporal lobe epilepsy with hippocampal sclerosis

Robert Carton, Michael G. Doyle, Hugh Kearney, Charles A. Steward, Nicholas Lench, Anthony S. Rogers, Erin L. Heinzen, Seamus McDonald, Joanna Fay, L.G. Austin, Alan Beausang, Jane Cryan, Francesca Brett, Hany El‐Naggar, Peter Widdess‐Walsh, Daniel J. Costello, Ronan Kilbride, Colin P. Doherty, Kieron J. Sweeney, Donncha F. O’Brien, David C. Henshall, Norman Delanty, Gianpiero L. Cavalleri, Katherine A. Benson   +23 more
openalex   +1 more source

Epilepsy, hippocampal sclerosis and amygdalar atrophy following H1N1-influenza-associated encephalopathy in an adult

, 2015
Shirin Karimi, Taufik A. Valiante, Tim‐Rasmus Kiehl   +2 more
openalex   +1 more source