Results 211 to 220 of about 511,468 (345)

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, EarlyView.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

Chronic reduction of synaptic proteins in the epileptogenic lesion of patients with hippocampal sclerosis. [PDF]

Front Mol Neurosci
Oota-Ishigaki A, Suzuki N, Iijima K, Takayama Y, Kimura Y, Hattori K, Iwasaki M, Hayashi T.   +7 more
europepmc   +1 more source

3D imaging of neuronal inclusions and protein aggregates in human neurodegeneration by multiscale x‐ray phase‐contrast tomography

Brain Pathology, EarlyView.
x‐ray phase‐contrast tomography enabled three‐dimensional, label‐free visualization and quantification of protein aggregates in neurodegenerative diseases with isotropic submicrometer resolution. The study revealed distinct electron density patterns in Lewy bodies, Hirano bodies, granulovacuolar degeneration, and amyloid plaques, highlighting their ...
Jonas Franz, Jakob Reichmann, Marina Eckermann, Thea Würfel, Artur Groh, Syed Fatima Qadri, Katja Schulz, Brit Mollenhauer, Christine Stadelmann, Tim Salditt   +9 more
wiley   +1 more source

ILAE type 3 hippocampal sclerosis in patients with anti-GAD–related epilepsy [PDF]

, 2015
Robert L. Glover, Lauren DeNiro, Patrick Lasala, Karen M. Weidenheim, Jerome Graber, Alexis Boro   +5 more
openalex   +1 more source

Homo sapiens, industrialisation and the environmental mismatch hypothesis

Biological Reviews, EarlyView.
ABSTRACT For the vast majority of the evolutionary history of Homo sapiens, a range of natural environments defined the parameters within which selection shaped human biology. Although human‐induced alterations to the terrestrial biosphere have been evident for over 10,000 years, the pace and scale of change has accelerated dramatically since the onset
Daniel P. Longman, Colin N. Shaw
wiley   +1 more source

Hypometabolic subtypes of AD are linked to comorbid hippocampal sclerosis and Lewy body pathology. [PDF]

Alzheimers Res Ther
Levin F, Dyrba M, Teipel SJ, Grothe MJ.
europepmc   +1 more source

Clinical Evaluation of a Quantitative Imaging Biomarker Supporting Radiological Assessment of Hippocampal Sclerosis. [PDF]

Clin Neuroradiol, 2023
Rebsamen M, Jin BZ, Klail T, De Beukelaer S, Barth R, Rezny-Kasprzak B, Ahmadli U, Vulliemoz S, Seeck M, Schindler K, Wiest R, Radojewski P, Rummel C.   +12 more
europepmc   +1 more source

Neurocognitive, behavioral, and treatment burden as key predictors of parental stress in pediatric epilepsy

Epilepsia, EarlyView.
Parental stress is linked to child cognitive impairment, internalizing symptoms, complex treatments, and lower caregiver education. No gender differences were found, though most caregivers were mothers. Findings suggest the need for support beyond seizure control.
Cinzia Correale, Mattia Mercier, Simona Cappelletti, Nicola Pietrafusa, Chiara Falamesca, Elisabetta Collalti, Giusy Carfi’ Pavia, Costanza Calabrese, Marina Trivisano, Luca De Palma, Francesca Cirulli, Nicola Specchio   +11 more
wiley   +1 more source

Predictive factors of long‐term outcomes of surgery for mesial temporal lobe epilepsy associated with hippocampal sclerosis

Epilepsia, 2017
B. Mathon, F. Bielle, S. Samson, O. Plaisant, S. Dupont, A. Bertrand, R. Miles, V. Nguyen-Michel, V. Lambrecq, A. Calderón-Garcidueñas, C. Duyckaerts, A. Carpentier, M. Baulac, P. Cornu, C. Adam, S. Clemenceau, V. Navarro   +16 more
semanticscholar   +1 more source

Mitogen-activated protein kinase phosphatase-2 deletion impairs synaptic plasticity and hippocampal-dependent memory [PDF]

, 2015
Ungless, MA
core   +1 more source