Results 221 to 230 of about 81,056 (343)

Motives and predictors of modified Atkins diet discontinuation as treatment of adults with drug‐resistant epilepsy

open access: yesEpilepsia, EarlyView.
Abstract Objective This study was undertaken to explore the motives and predictors of modified Atkins diet (MAD) discontinuation as a treatment of adults with drug‐resistant epilepsy (DRE). Methods A single‐center observational longitudinal study was made of a cohort of patients treated with MAD during the first 6 years at a multidisciplinary ...
Raquel Samões   +6 more
wiley   +1 more source

Characteristics, therapeutic pathway and the economic burden of patients with drug‐resistant epilepsy: A real‐world analysis following the introduction of cenobamate in Italy

open access: yesEpilepsia, EarlyView.
Abstract Objectives Drug‐resistant epilepsy (DRE) remains a major clinical challenge, affecting approximately one‐third of patients with epilepsy. Cenobamate, a novel antiseizure medication (ASM) approved in Italy in 2022, has shown promise in clinical trials. However, real‐world data on its use, especially economic evaluations, remain limited.
Valentina Perrone   +27 more
wiley   +1 more source

The interacting etiologies of hippocampal sclerosis in epilepsy: A scoping review

open access: yesEpilepsia, EarlyView.
Abstract According to the International League Against Epilepsy classification, mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE‐HS) is considered an epilepsy syndrome. Several etiologies may precede HS, but there is little overview in the literature about these etiologies.
Boris Deleu   +2 more
wiley   +1 more source

C1q neutralization during epileptogenesis attenuates complement‐mediated synaptic elimination and epileptiform activity

open access: yesEpilepsia, EarlyView.
Abstract Objective Accumulating evidence indicates that aberrant C1q‐C3 complement signaling in microglia and astrocytes drives synaptic dysfunction and neuronal loss. C1q‐mediated synaptic dysfunction disrupts neuronal circuitry balance and can lead to network hyperexcitability in epilepsy.
Yoonyi Jeong   +5 more
wiley   +1 more source

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