Results 221 to 230 of about 511,468 (345)

Drug discovery and preclinical testing of drug candidates for developmental and epileptic encephalopathies

Epilepsia, EarlyView.
Abstract Drug development for developmental and epileptic encephalopathies (DEEs) follows different strategies on one hand including disease‐targeting precision medicine approaches considering the genetic variants and pathomechanisms in DEEs and on the other hand including therapeutic approaches with novel targets or second‐generation drug candidates ...
Heidrun Potschka, Daniel Pérez‐Pérez
wiley   +1 more source

Bilateral ictal EEG is associated with better memory outcome after hippocampal sclerosis surgery. [PDF]

Epilepsia Open, 2023
Castro-Lima H, Passarelli V, Ribeiro ES, Adda CC, Preturlon-Santos APP, Jorge CL, Valério R, Tzu WH, Boa-Sorte N, Pipek LZ, Castro LHM.   +10 more
europepmc   +1 more source

Hippocampal internal architecture and postoperative seizure outcome in temporal lobe epilepsy due to hippocampal sclerosis [PDF]

, 2016
Samia Elkommos, Bernd Weber, Pitt Niehusmann, Elisa Volmering, Mark P. Richardson, Yen Y. Goh, Anthony G Marson, Christian E. Elger, Simon S. Keller   +8 more
openalex   +1 more source

Exploratory study of peripheral immune changes associated with diffusion MRI multi‐compartment model in temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Studies in temporal lobe epilepsy (TLE) have shown that focal inflammation is a key contributor to seizure initiation and maintenance. However, most in vivo studies to date have focused on positron emission tomography (PET) findings. In this exploratory study, we assessed the relationship between multicompartment Neurite Orientation ...
Jerzy P. Szaflarski, Rodolphe Nenert, Huixian Hong, Christina Mueller, Ayushe A. Sharma, Hongwei Qin, Etty N. Benveniste   +6 more
wiley   +1 more source

Association between enlarged perivascular space (ePVS) density and stereo‐electroencephalography (SEEG) biomarkers of epileptogenicity

Epilepsia, EarlyView.
Abstract Objective We aim to explore the association between enlarged perivascular space (ePVS) density and stereo‐electroencephalography (SEEG) biomarkers of epileptogenicity. Methods We retrospectively analyzed consecutive SEEG patients from an Australian site.
Jacob Bunyamin, Benjamin Sinclair, Thanomporn Wittayacharoenpong, Parveen Sagar, William Pham, Zhibin Chen, Noam Bosak, Joshua Laing, Matthew Gutman, Martin Hunn, Patrick Kwan, Terence J. O'Brien, Meng Law, Andrew Neal   +13 more
wiley   +1 more source

<i>TMEM14A</i> Gene Affects Hippocampal Sclerosis in Mesial Temporal Lobe Epilepsy. [PDF]

J Clin Med
Kim J, Cho S, Jeong KH, Ha WS, Kim KM, Chu MK, Lee JH, Kim S, Kim WJ.   +8 more
europepmc   +1 more source

MRI‐negative epilepsy: A systematic review and meta‐analysis

Epilepsia, EarlyView.
Abstract Objective Drug‐resistant focal epilepsy is commonly dichotomized based on magnetic resonance imaging (MRI) lesion visibility into positive (MRI‐pos) and negative (MRI‐neg). Yet, the criteria used to ascribe such categorization are variable.
Ravnoor S. Gill, Francesco Deleo, Boris Bernhardt, Samuel Wiebe, Neda Bernasconi, Andrea Bernasconi   +5 more
wiley   +1 more source

Hippocampal sclerosis in association with Sturge-weber syndrome: An intertwining of 2 epileptogenic lesions. [PDF]

Radiol Case Rep
AlAlwan MQ, Alsaad FA, Alhashem HY, Altaweel I, AlAlwan QM, Al Obaid JJ, Almohammed Ali HA.   +6 more
europepmc   +1 more source

Haploinsufficiency of brain‐specific kinase BRSK1 causes epilepsy and neurodevelopmental disorders

Epilepsia, EarlyView.
Abstract Objective The BRSK1 gene encodes brain‐specific serine/threonine kinase 1 (also known as SAD‐B kinase), which is almost exclusively expressed in the brain and plays critical roles in neuronal polarization, neurotransmitter release, mitochondrial dynamics, and neuronal maturation.
Qi Zhang, Hiroshi Yamanaka, Ping Li, Yingfeng Li, Tian Luo, Miao Xia, Ting Liu, Xueyan Liu, Qing Lu, Bin Yang, Fan He, Kaixian Du, Yousheng Shu, Bo Peng, Yong‐hui Jiang, Yi Wang   +15 more
wiley   +1 more source

Abnormal Synchronization Between Cortical Delta Power and Ripples in Hippocampal Sclerosis. [PDF]

Ann Clin Transl Neurol
Iwata T, Yanagisawa T, Fukuma R, Ikegaya Y, Oshino S, Tani N, Khoo HM, Sugano H, Iimura Y, Suzuki H, Kishima H.   +10 more
europepmc   +1 more source