Results 271 to 280 of about 511,468 (345)

TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models

The FEBS Journal, EarlyView.
The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir, Joerg Buddenkotte, Majid Ali Alam, Ahmed Own, Randall J. Eck, Brian C. Kraemer, Eckhard Mandelkow, Martin Steinhoff   +7 more
wiley   +1 more source

Chinese Verbal Fluency Deficiency in Temporal Lobe Epilepsy with and without Hippocampal Sclerosis: A Multiscale Study. [PDF]

J Neurosci
Wang K, Xie F, Liu C, Wang G, Zhang M, He J, Tan L, Tang H, Xiao B, Wan L, Long L.   +10 more
europepmc   +1 more source

Syndrome of mesial temporal lobe epilepsy associated with hippocampal sclerosis: clinical and electrophysiological characteristics

S. E. Vasina
openalex   +2 more sources

Co‐localization of tau and TDP‐43 after extracellular vesicle delivery to cells

The FEBS Journal, EarlyView.
Extracellular vesicles (EVs) derived from donor cells transfected with EGFP–2N4R‐tau or mCherry‐wtTDP‐43 were taken up by recipient cells, leading to cytosolic co‐localization of tau and TDP‐43. Molecular modeling revealed that tau and TDP‐43 directly interact through hydrogen bonding, suggesting a mechanistic link underlying their co‐pathology ...
Farhang Aliakbari, Kathryn Volkening, Zahra Nayeri, Aysegul Yucel Polat, Neil Donison, Jacqueline Palik, Michael J. Strong   +6 more
wiley   +1 more source

Cytoplasmic expression of trans-active response DNA-binding protein-43 in aged mice display hippocampal sclerosis-like degeneration and neuronal loss with reduced lifespan. [PDF]

J Neuropathol Exp Neurol
Anderson AJ, Dopler MB, Arezoumandan S, Osei-Kankam D, Davis SA, Ajroud K, Lilek J, Bambakadis E, Shapiro R, Flanagan ME, Cairns NJ, Gitcho MA.   +11 more
europepmc   +1 more source

Automated and Interpretable Detection of Hippocampal Sclerosis in temporal lobe epilepsy: AID-HS

, 2023
Ripart M, DeKraker J, Eriksson MH, Piper RJ, Mo J, Su T, Kochi R, Wang I, Winston GP, Clark CA, D’Arco F, Mankad K, Khan AR, Baldeweg T, Adler S, Wagstyl K.   +15 more
europepmc   +1 more source

Genomics and CSF analyses implicate thyroid hormone in hippocampal sclerosis of aging

Acta Neuropathologica, 2016
P. Nelson, Y. Katsumata, K. Nho, S. Artiushin, G. Jicha, Wang-Xia Wang, E. Abner, A. Saykin, W. Kukull, D. Fardo, Alzheimer's Disease Neuroimaging Initiative   +10 more
semanticscholar   +1 more source

Measurement of brain volume using MRI:software, techniques, choices and prerequisites [PDF]

, 2010
Keller, Simon S., Roberts, Neil
core  

Tui Na Acupressure Modulates Treg Immunosuppression via FoxP3/mTORC1 Signalling in ALS Mice

Immunology, EarlyView.
The proposed mechanism by which Tui Na acupressure improves motor and cognitive dysfunction in ALS mice by activating the FoxP3/mTORC1 pathway. ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease driven by neuroinflammation, where regulatory T cell (Treg) dysfunction exacerbates immune imbalance.
Jie Han, Xi Xu, Yan Zhao, Yao Xiao, Fei Huang, Jing Zhou, Hai Huang, Guiqian Wang   +7 more
wiley   +1 more source

Infiltration of T Lymphocytes and Expression of ICAM-1 in the Hippocampus of Patients with Hippocampal Sclerosis

, 2010
Hiroaki Nakahara, Yoshihiro Konishi, Thomas G. Beach, Naoto Yamada, Satoshi Makino, Ikuo Tooyama   +5 more
openalex   +2 more sources