Cytoplasmic expression of trans-active response DNA-binding protein-43 in aged mice display hippocampal sclerosis-like degeneration and neuronal loss with reduced lifespan. [PDF]
J Neuropathol Exp NeurolAnderson AJ +11 more
europepmc +1 more source
Tui Na Acupressure Modulates Treg Immunosuppression via FoxP3/mTORC1 Signalling in ALS Mice
Immunology, Volume 177, Issue 3, Page 481-500, March 2026.The proposed mechanism by which Tui Na acupressure improves motor and cognitive dysfunction in ALS mice by activating the FoxP3/mTORC1 pathway. ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease driven by neuroinflammation, where regulatory T cell (Treg) dysfunction exacerbates immune imbalance.
Jie Han +7 more
wiley +1 more source
The use of automated and AI-driven algorithms for the detection of hippocampal sclerosis and focal cortical dysplasia. [PDF]
EpilepsiaBernasconi A, Gill RS, Bernasconi N.
europepmc +1 more source
Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder
Journal of Internal Medicine, Volume 299, Issue 3, Page 302-327, March 2026.Abstract Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti‐seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and
Marco Ledri, Merab Kokaia
wiley +1 more source
The role of HG in the analysis of temporal iteration and interaural correlation [PDF]
, 2004 Barrett, DJK, Hall, DA
core
Long‐term amyloid PET and MRI outcomes in a menopausal hormone therapy trial
Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract INTRODUCTION Associations of short‐term use of menopausal hormone therapy (mHT) with Alzheimer's disease (AD) and structural magnetic resonance imaging (MRI) biomarkers were investigated 10 years after an mHT trial. METHODS Recently menopausal women with good cardiovascular health were randomized to oral conjugated equine estrogens (oCEE) or ...
Kejal Kantarci +27 more
wiley +1 more source
Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimer's disease
Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract INTRODUCTION Although it has become clear that alterations in lipid metabolism are associated with Alzheimer's disease (AD), it is unclear how they contribute to both cognitive decline and the pathophysiology of AD. METHODS Lipidomics and activity‐based protein profiling (ABPP) were performed in the frontal cortex of control, AD and resilient ...
Daan van der Vliet +12 more
wiley +1 more source
Investigating the effect of hippocampal sclerosis on parietal memory network. [PDF]
Epilepsia OpenEthofer S +5 more
europepmc +1 more source
Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling
Brain and Behavior, Volume 16, Issue 2, February 2026.Histone methylation and acetylation modulate gene expression by inducing chromatin condensation or relaxation, which in turn regulates transcriptional activity and impacts neurogenesis. ABSTRACT Aims The purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression ...
Degisew Yinur Mengistu +1 more
wiley +1 more source